ID A0A3B3BUG9_ORYME Unreviewed; 2877 AA.
AC A0A3B3BUG9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Fibrillin 1 {ECO:0000313|Ensembl:ENSOMEP00000008452.1};
GN Name=FBN1 {ECO:0000313|Ensembl:ENSOMEP00000008452.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000008452.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000008452.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the fibrillin family.
CC {ECO:0000256|ARBA:ARBA00008972}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 30732.ENSOMEP00000008452; -.
DR PaxDb; 30732-ENSOMEP00000008452; -.
DR Ensembl; ENSOMET00000002425.1; ENSOMEP00000008452.1; ENSOMEG00000009742.1.
DR GeneTree; ENSGT00950000183158; -.
DR OMA; DRLDCVD; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0001527; C:microfibril; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd11304; Cadherin_repeat; 1.
DR CDD; cd00054; EGF_CA; 31.
DR Gene3D; 2.10.25.10; Laminin; 46.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 9.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR049388; FBN_EGF_N.
DR InterPro; IPR040872; Fibrillin_U_N.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR47333:SF2; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47333; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 39.
DR Pfam; PF21364; FBN_EGF_st1; 1.
DR Pfam; PF18193; Fibrillin_U_N; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00683; TB; 9.
DR PIRSF; PIRSF036312; Fibrillin; 1.
DR SMART; SM00181; EGF; 47.
DR SMART; SM00179; EGF_CA; 44.
DR SUPFAM; SSF57196; EGF/Laminin; 9.
DR SUPFAM; SSF57184; Growth factor receptor domain; 12.
DR SUPFAM; SSF57581; TB module/8-cys domain; 9.
DR PROSITE; PS00010; ASX_HYDROXYL; 40.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 27.
DR PROSITE; PS50026; EGF_3; 41.
DR PROSITE; PS01187; EGF_CA; 14.
DR PROSITE; PS51364; TB; 9.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..2877
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017452232"
FT DOMAIN 156..188
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 194..237
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 256..297
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 298..339
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 344..390
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 453..491
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 495..534
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 535..576
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 577..613
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 618..658
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 664..716
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 728..765
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 770..811
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 812..851
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 856..895
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 915..956
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 961..1012
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1033..1074
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1075..1117
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1118..1159
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1160..1201
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1243..1284
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1285..1322
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1327..1367
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1368..1408
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1409..1450
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1451..1487
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1492..1532
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1537..1595
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1612..1653
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1654..1690
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1699..1754
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1772..1813
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1814..1854
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1855..1896
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1897..1932
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1936..1977
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1978..2017
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2018..2059
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2064..2117
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2131..2166
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2169..2208
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2250..2293
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2294..2335
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2340..2393
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2405..2446
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2496..2532
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2535..2577
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2578..2617
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2618..2654
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 160..170
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 178..187
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 499..509
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 816..826
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1901..1911
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2135..2145
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2582..2592
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2877 AA; 312646 MW; 1344168B85E2E9C0 CRC64;
MRDSARGERL PQLVVALLAL LSLFAGLGDP AEVVDVDDKE AVTKIADTRA NRAKRRGGTD
VLRGPNVCGS RNNAYCCPGW KTLTGGNQCI VPICRSLCGD GFCSRPNLCT CPNGQIAPSC
GSKSGIQNCN IRCMNGGTCA EDNCLCQKGY VGNHCGQPVC ENGCLNGGRC VAPNRCVCTY
GFTGAQCERD YRTGPCFASV NNQMCQGQLT GIVCTKTLCC ATVGRAWGHP CEMCPAQPHP
CRRGFIPNHR TGACQDVDEC HAIPGICQGG NCINTVGSFE CKCPAGHKFH EISQKCEDLD
ECSNIPGLCG VGECSNTVGS YFCKCPQGYY TSVDGSRCID GRGGYCYASL LNGRCANQNS
QLLTKMQCCC DSGRCWSDGS TPEMCPIRGT GGVAHLVFPG PGPRPDMPNV YPVPRPDRPR
IYEPPPIPER ERIPDHIPEQ IPVLPQPQVL PFASNACQAF RNLCLNGRCV PLPGGSYRCE
CNMGFKLDRR GECIDDDECE RNPCAHGECV NTPGSYICQC PAGFQSTATR TECRDLDECV
ANGRICNNGR CVNTEGSFHC VCNAGFEISA DGKNCQDQDE CLIRNMCLNG LCINEDGSFK
CICKSGFLLD TSGRMCVDID ECETPGMCMN GHCVNTEGSF RCECMAGMAV GLDGRVCVDT
HMRSTCYGGY NRGQCVRPLF GAVTKSECCC ASTEYAYGEP CQPCPRESSA EFQALCPSGG
GTTGDGRDIN ECALDPDICQ NGVCENMLRT YKCTCNVGFE VDLSGKNCVD INECMMNSLL
CDNGLCRNTP GSFTCQCFKG FRFDPETEVC EDINECESNP CINGDCVNSQ GSFVCTCSAG
SSLDSTGLEC IETVKSTCWL KIVNNRCEVN INGATLKSHC CATLGEAWNS PCAKCEKDPI
CGKGFARVKG NVCEDVDECQ VFPGVCINGK CVNTQGSFFC QCPPGMTVDV SGRTCIDLRT
EHCYLTHDDE RCGTPISGRH RVDACCCSVG VAWGPECDEC PENGTPEFAQ LCPRGPGFSH
RGDFINGRPF LKDINECRMI NTLCSNGRCR NTIGSFRCRC DNGFALDADE RNCTDIDECR
ISPDLCGQGT CVNTPGDFEC NCFEGFESGF MMMKNCMDID ECERNPQLCR GGECVNTEGS
FQCVCPPGHE ITPDGSACLD INECELSDRL CRNGQCVNMV GSYYCNCNTG YKSTEDLVNC
VDIDECMIEN GGCETFCTNS EGSYECSCNN GYALMPDQRS CIDIDECEEN PNTCDGGQCT
NTPGTYQCLC FDGFMSSEDM KSCLDVDECE LNSNICLSGN CENTKGSFIC HCDLGYSVRK
GTTGCTDINE CEIGAHNCDR QATCTNTAGS FKCNCAPGWI GNGLKCTDLD ECSNGTHTCN
NNAECQNTLG SYRCVCKEGY FGDGFFCSDS DECAENGNLC ESGHCLNLPG GFRCECDMGF
IATDDGKACK DIDECTFADI CVNGRCQNIP GLFRCECNIG YELDRSGGNC TDINECADPT
TCINGICVNI PGNYHCNCPP DFELNPTGVG CVDTRSGSCY LNARARGDAS ESYECSQEIG
VGVSKASCCC SEGAGWGSPC EACPHVNSTG YKTLCPGGEG FRPNPITVIL EDINECQELP
GLCQGGQCIN TFGSFQCECP RGFSLNFDTR VCEDINECEN PGICGPGQCY NTIGNYTCIC
PADYMPVNGG NNCMDMRKSY CYRNFYLDNG TCDGELTFNM TKKMCCCSYN IGRAWNKPCE
QCPVPSTDEF AILCGSERPG YYIDITTGRV IDIDECREIP GVCENGVCIN MIGSFRCECP
IGFIYNDKLL ICEDIDECQN GPVCQQHANC FNMPGSFRCE CEAGYRLTST GQCLDRNECN
ENPGVCNPGQ CIDTLGSYRC LCPNGYKTTK DLSMCVDVDE CERQPCGNGT CKNTLGSYNC
LCYPGFQNSH NGDCIDVDEC STQRGLCRNG QCLNIVGSFL CVCNDGYELS LDGRVCTDIN
ECAVNPGTCG AGTCVNMDGS YRCICPPGYY LHEETCEDID ECSQSPEICT FGTCSNTEGS
FTCQCPEGFQ LSASGRRCLD IRVNYCFTKF ENGRCTAPKP QNTSKEACCC TRMPGQGWGD
PCEICPPKDQ EAYRVLCPTE GYERKDDHPT DINECLNNPC VNGQCINTDG SFRCECPMGY
SLDNTGVTYI NECEVGNPCG NGTCTNVIGG FECSCDEGFE PGPMMTCEDI NECAHNPLLC
AFRCVNVVGS YECKCPTGYI LREDRRMCKD QNECEDGIDD CASRGMTCKN LIGTFMCICS
PGYTRHPSGD SCIDLNECAT KPGICKNGRC ENTVGSYRCR CAQGFVANPT QTECIDNRED
FCYTEVLTTL CQMSSSNRNL VTKSECCCDG GRGWGINCEL CPLPGTSQYK KMCPLGPGYT
TDGRDIDECR VMGNLCKNGQ CVNSIGSYKC ICKPGYTTDI TATQCVEKKQ PHPLSLLEFL
FYLFPCNFIC KNTEGSYLCS CPRGYILQEN GKSCRDLDEC STKQHNCQFL CINTIGGFTC
KCPPGFTQHH SACIDNNECS TDPNLCGSNG VCQNTPGSFN CDCQRGFSLD SSGQTCEDMD
ECDGNHRCQH GCQNLVGGYR CSCPQGYLQH YQWNQCVDEN ECLNTQICGG ASCHNTLGSF
RCLCPSGFDF EQASGGCADI NECSTTQNPC KFGCSNTDGG YLCGCPPGYL RAGQGHCVTG
VGFTSGSPIG EQGGEMDENS LSPEACYECK INGYPKKGRK RRTFLASFSQ QFTEEVSLAS
LDIEDTLQFH LNISDLSNRD HILELTPALS TLSDHVRYSI DSGNEQGFFR INQREGVSYL
HFSKKVAPLP GTYHLQISSI PLYRKMELAK LEDQHDKDYL TGQLGDILKM RVQLVLH
//
