ID   A0A3B3BX05_ORYME        Unreviewed;      1225 AA.
AC   A0A3B3BX05;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=NACHT, LRR and PYD domains-containing protein 12-like {ECO:0000313|Ensembl:ENSOMEP00000009342.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000009342.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000009342.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B3BX05; -.
DR   Ensembl; ENSOMET00000000926.1; ENSOMEP00000009342.1; ENSOMEG00000010658.1.
DR   GeneTree; ENSGT01070000253760; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR029495; NACHT-assoc.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR   PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR   Pfam; PF14484; FISNA; 1.
DR   Pfam; PF13516; LRR_6; 5.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   SMART; SM01288; FISNA; 1.
DR   SMART; SM00368; LRR_RI; 11.
DR   SUPFAM; SSF52047; RNI-like; 2.
DR   PROSITE; PS51450; LRR; 2.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
FT   DOMAIN          303..437
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          93..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          176..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        100..114
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        117..156
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        190..205
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1225 AA;  138473 MW;  CD55735B6DB666F7 CRC64;
     MDQCEDTQEG APPSKITLCG EDESKSKAQR NQREPGYEPS LVSFSSDFSK DLPLNFKGKH
     KSLSNAQRNQ PGYGYEPSCV SFSSDFSKDL PLNFKGSSSG EHKSHNEERN QREPGYEPSC
     VSFSSDFSKD LPLNFKGSSS GKHKSQSKAQ RNQPGYGYEP SCVSFSSDFS KDLPLNFKGS
     SSGKHKSLSN AQSIHRERKR SGLQAAERPQ SDVGLREIFI EHKISLKKRS EHVAEGFEEA
     GRETLLSRVY TELYITEELR EEVHTQHEVM QLETTTKTNK LNFTAIKNPD IFKVFRDQHR
     SIRVVLTSGV AGAGKSFSVQ KFSLDWAEGL ENQDINAVVP LSFREMNLIR DEQHSLLTLI
     QLFHPTLQKI PGEQLSVCKL LFIFDGLDES RLSLDFNNSP VVSDVTQKSS VSVLLTNLIQ
     GRLLPSALVW ITSRPAAASQ IPRSRVDRLT EVRGFNDVQK EEYFRRRFSD EELSNRVISH
     IKGSMSLYIM CEVPVFCWIT AVVLENMLTT KKKRKLPTTL TDMYSHFLMV QTKRKKNKYQ
     QDHETSPQEL TETDGDVLLK LGRLAFEHLE KGNIMFYQED LQQCGLDVTE ASVYSGVCTE
     IFRRECEIFQ KLVYSFVHLS VQEFLAAVYM FHCYSNRKVN VIEDFLKCDM KNPSLDEFLR
     MIIEKSLQSK TGHLDLFVRF LHGLSVKSNQ RLLGGLLGQS EKNQAIFQKI INNLKEINSV
     EVSPDRSINI YHCLMEMKDL SVHQEIQEFL KSENKTVINL SEIHCSALAY TLKMSEELLE
     DLDLNQYNTS YEGKRRLVPA VRICKKFRTP ERCRLSETDY EIVASALKSN PSHLIELDLT
     SNDMEDLSMV EVLCSGLERP NCRLQTLRLE SCSLSEMSCK ALGSALKSNP SSLTELNLGR
     NDLEDAGFLH FRGFLESPDC RLQILRLKDC SLSEISCKAL GSALKSNPSN LTELDLSQND
     LQDSGLLHLR GFLESPVCKL KILRLWRCGL SETSCEALGS ALKSNPSNLT ELELSHNNLE
     DSGFLHLRGF LESPVCRLQI LKLWSCKLSE ISCEVLGSAL KSNPSNLTEL DLSWNTGMQD
     SGFLHLEGFL KSPDCRLQIL RLNNCGLSEI SLEALVSALK HNPANLTELH FSHNKVHGSG
     FLHLWSFLAN PGCRLQILRL EFSSLSNINC EALVSALKSN PSHLIELNLG FNNLQESDGQ
     QLQDLLESPN FKLQDLSWKG TGWWS
//