ID A0A3B3BY29_ORYME Unreviewed; 386 AA.
AC A0A3B3BY29;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Basic helix-loop-helix family, member e41 {ECO:0000313|Ensembl:ENSOMEP00000009953.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000009953.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000009953.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3B3BY29; -.
DR STRING; 30732.ENSOMEP00000009953; -.
DR PaxDb; 30732-ENSOMEP00000009953; -.
DR Ensembl; ENSOMET00000016633.1; ENSOMEP00000009953.1; ENSOMEG00000011218.1.
DR GeneTree; ENSGT00940000161014; -.
DR OMA; KKPKMNW; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0009409; P:response to cold; IEA:Ensembl.
DR GO; GO:0030431; P:sleep; IEA:Ensembl.
DR Gene3D; 6.10.250.980; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR PANTHER; PTHR10985:SF76; CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 41; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 4: Predicted;
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 44..99
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 130..165
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
FT REGION 206..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 386 AA; 42433 MW; 53E43F699A3ED8D2 CRC64;
MDERIAHLQD RQFVEHADFL VDYPPLYMCK SKRGIKREDG GKDAYKLPHR LIEKKRRDRI
NECIGQLKDL LPEHLKLSTL GHLEKAVVLE LTLKHLNALT AVTEQQHQKI IALQNDRSLN
SPIHADLDAF HSGFQACAKE VLQYLNQVEN WTAREQRCAQ LVNHLHKALA QFQPGAPALQ
HQLPAGDAHD AQKADGQANC VPVIQRTQGG ELNENDTDTD SGYGGETEKS EGKEKECSSA
QGLKAVKIKQ EFGDERAAKK PKMSWTGKGV AGADQTRPDL TFMNSLMGIS SVGQQTPICM
PFYFINPSAA ASYMPFFDKN NMEKYVYPAA AALASPFPWL YPAHAAAAAA AAFPGLSAHF
GASPQPKDAR SPDNDGSYEA DAASSE
//
