ID A0A3B3BYW9_ORYME Unreviewed; 419 AA.
AC A0A3B3BYW9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Splicing factor 45 {ECO:0000256|PIRNR:PIRNR031066};
DE AltName: Full=RNA-binding motif protein 17 {ECO:0000256|PIRNR:PIRNR031066};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000010765.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000010765.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Splice factor that binds to the single-stranded 3'AG at the
CC exon/intron border and promotes its utilization in the second catalytic
CC step. Involved in the regulation of alternative splicing and the
CC utilization of cryptic splice sites. {ECO:0000256|PIRNR:PIRNR031066}.
CC -!- SUBUNIT: Associates with the spliceosome.
CC {ECO:0000256|PIRNR:PIRNR031066}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR031066}.
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DR AlphaFoldDB; A0A3B3BYW9; -.
DR STRING; 30732.ENSOMEP00000010765; -.
DR PaxDb; 30732-ENSOMEP00000010765; -.
DR Ensembl; ENSOMET00000017666.1; ENSOMEP00000010765.1; ENSOMEG00000012060.1.
DR GeneTree; ENSGT00790000123099; -.
DR OMA; FDKHRTS; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR CDD; cd12647; RRM_UHM_SPF45; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR040052; RBM17.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR InterPro; IPR034653; SPF45_RRM.
DR PANTHER; PTHR13288:SF8; SPLICING FACTOR 45; 1.
DR PANTHER; PTHR13288; SPLICING FACTOR 45 SPF45; 1.
DR Pfam; PF01585; G-patch; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF031066; Splicing_factor_SPF45; 1.
DR SMART; SM00443; G_patch; 1.
DR SMART; SM00361; RRM_1; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50174; G_PATCH; 1.
DR PROSITE; PS50102; RRM; 1.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|PIRNR:PIRNR031066};
KW mRNA splicing {ECO:0000256|PIRNR:PIRNR031066};
KW Nucleus {ECO:0000256|PIRNR:PIRNR031066};
KW RNA-binding {ECO:0000256|PIRNR:PIRNR031066, ECO:0000256|PROSITE-
KW ProRule:PRU00176}; Spliceosome {ECO:0000256|PIRNR:PIRNR031066}.
FT DOMAIN 235..275
FT /note="G-patch"
FT /evidence="ECO:0000259|PROSITE:PS50174"
FT DOMAIN 323..407
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 56..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 419 AA; 46145 MW; F89EDFCF9479D9E5 CRC64;
MSLYDDLGVG ASDTKTEGWS KNFKLLQSQL KVKKAALTQA KTQRVKQTTV LAPVIDLKRG
GSSEERQSTD TPPHAALMDA VPSGFSAGDV LIPLADEYDP MFPNDYEKVM KRHREERQRQ
REQERQKEIE EREKRRKDRH EGGAPSGFSR FPAAEEDSDE DEEYERERRK RSMGGAAIAP
PSSLVDRDGS SSFSYEDEGR SSRGPKVAIP PPMYEDSDRP RSPPGPTSSF LANMGGTVAH
KIMQKYGFKE GQGLGKHEQG LSTALSVEKT SKRGGKIIIG DAAEKPGSSQ AGAAEIPGGG
AAADPSKKSE SNPLTEILKN PTKVVLLRNM VGRGEVDEDL EGETKEECEK YGKVVKCVIF
EIADVPDDEA VRIFLEFERV ESAIKAVVDL NGRYFGGRVV KACFYNLDKF RVLDLGEQV
//
