ID A0A3B3C1C9_ORYME Unreviewed; 1182 AA.
AC A0A3B3C1C9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=DAB2 interacting protein {ECO:0000313|Ensembl:ENSOMEP00000011635.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000011635.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000011635.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3C1C9; -.
DR Ensembl; ENSOMET00000018771.1; ENSOMEP00000011635.1; ENSOMEG00000013086.1.
DR GeneTree; ENSGT00940000155853; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF26; DISABLED HOMOLOG 2-INTERACTING PROTEIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12004; DAB2P_C; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468}.
FT DOMAIN 165..199
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 190..308
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 368..560
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 653..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 705..815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 837..992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1156..1182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1021..1094
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1124..1151
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 35..54
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..750
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..807
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..859
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 890..916
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 945..991
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1182 AA; 131788 MW; B875F7523A333222 CRC64;
MAGVTRKGSG RPSYYYRFLG KSRLQRQRSR SRSRTRSSAT RESPPERTGR RRSMPGSADK
SSATMEPSST AATPFRVTGF LSRRLKGSIK RTKSQPKLDR NASFRHILPN FRSFDHDRSQ
LMPRLKESRS HESLLSPSSA VEALDLSMED EVIIKPVHSS ILGQDYCFEV TTSTGSKCFS
CRSAAERDKW MENLRRAVQP NKDNSRRVEN ILRLWVIEAK DLPAKKKYFC ELCLDESLYA
RTTCKLKTDN VFWGEHFEFS NLPAVRSITA HLYKDTDKKK KKDKNNYIGL VNIPVAAVSG
RQFVEKWYPV STPNPPKGKT SGPMIRIKTR YQSMSILPME MYKEFAEYTT NNYMLLCSVL
EPGISVKNKE EMACALVHIL QSTGKAKDFL TDLMMSEVDR CGENEHLIFR ENTLATKAIE
EYLKLVGQKY LQDTLGEFIK ALYESDENCE VDPSKCSSGD LPDHQSNLKM CCELAFCKII
KSYCFFPREL KEVFASWRQE CSSRGRPDIS ERLISASLFL RFLCPAIMSP SLFNLTQEYP
DDRTARTLTL IAKVTQNLAN FTKFGNKEEY MSFMNQFLEH EWSDMQRFLL EISNPETISN
TAGFEGYIDL GRELSTLHSL LSEVVSQMDQ SVASKLGPLP RVLREVNNAL SNPSCVQMTP
GQSSEQVNSP PAEAGCSIST GLQKMVIDSD LSGLVDFTRL PSPTPENKDL FFVTKSSGIQ
PSPARSSSYS ETNEPDQGMA NGSKSLSMLD LQDPRSLDGG SGPSPSDGLE GLASGSCWAA
KVPQGNTPGG PTLRRPGQTT TTPGAEGTPG RPAQLLAPLS FQNPVYQMAA CLPVSPRGMA
DSGSECHSSV SSHSNNEDGP PGGKQAFLNP AGGGGGSSGD EYTRRPGEAN RRQLSLTETQ
HQPSIPRQNS AGPQRRIDQP PPQLLNRGRT PPNLLGGGPY PRPSSGSMMA SSPDWPASGA
RLRQQSSSSK GDSPETKQRV QHKQAPSPVN PSALDRTAAW LLNMNAHYLD HEGLETESLR
NREDLTQVEK YQQEIAVLQE KLRASVQKLE EYEARLKGQD EQAQKVLMEY QARLEESEER
LRRQQDDKDL QMKSIISRLM SVEEELKKDH SDMQAVVDSK QKIIDAQEKR IASLDAANAR
LMSALAQLKE RYSMQTRNGI SPTNPTKLQI TENGEFRNSS NC
//
