ID   A0A3B3C240_ORYME        Unreviewed;       313 AA.
AC   A0A3B3C240;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Interleukin-1 {ECO:0000256|RuleBase:RU003753};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000011127.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000011127.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}. Lysosome
CC       {ECO:0000256|ARBA:ARBA00004371}. Secreted, extracellular exosome
CC       {ECO:0000256|ARBA:ARBA00004550}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000256|ARBA:ARBA00010448,
CC       ECO:0000256|RuleBase:RU003753}.
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DR   AlphaFoldDB; A0A3B3C240; -.
DR   STRING; 30732.ENSOMEP00000011127; -.
DR   PaxDb; 30732-ENSOMEP00000011127; -.
DR   Ensembl; ENSOMET00000032196.1; ENSOMEP00000011127.1; ENSOMEG00000012409.1.
DR   GeneTree; ENSGT00390000016316; -.
DR   OMA; HEGKHQY; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   Gene3D; 2.80.10.50; -; 1.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR008996; IL1/FGF.
DR   PANTHER; PTHR10078:SF30; INTERLEUKIN-1 BETA; 1.
DR   PANTHER; PTHR10078; INTERLEUKIN-1 FAMILY MEMBER; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; Cytokine; 1.
PE   3: Inferred from homology;
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Secreted {ECO:0000256|RuleBase:RU003753}.
SQ   SEQUENCE   313 AA;  36034 MW;  280C1B8A3ECAB303 CRC64;
     MILWNLTNDF RTGDHLIGMD GISLDNFTPE DLARSLSEGN ISKLTVQKTT RQKDQIEEEP
     PQGAIFDSEE FTVMSFSWKM KREKELEQHQ NIKNEVNKGV ETSDLLVIKM RKTTVSVMIG
     RGCPSKSKGM DIPRTSCAVE EIVLVAESSN VTLVPRGDGM FRLEKLSEVF IEHKPSHRYL
     KRICSKTGLY TSPNPEKVTI YYYKSNIMEK TYRGMPVALN FTNSNCFLKC CKEGEDVVLQ
     IETYEKSSLR QISKSDDNAL AFVFYMKADR TKLRKFESAL YEGWFICVQE STKAEVEPLN
     DMREEMFLFI IQK
//