ID A0A3B3C279_ORYME Unreviewed; 1120 AA.
AC A0A3B3C279;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=BK channel {ECO:0000256|ARBA:ARBA00029579};
DE AltName: Full=Slowpoke homolog {ECO:0000256|ARBA:ARBA00033447};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000011935.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000011935.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the potassium channel family. Calcium-activated
CC (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
CC {ECO:0000256|ARBA:ARBA00008648}.
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DR AlphaFoldDB; A0A3B3C279; -.
DR Ensembl; ENSOMET00000019150.1; ENSOMEP00000011935.1; ENSOMEG00000013582.1.
DR GeneTree; ENSGT00940000154935; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR048735; Slowpoke-like_C.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF41; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF21014; Slowpoke_C; 1.
DR PRINTS; PR01449; BKCHANNELA.
DR PRINTS; PR00169; KCHANNEL.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 36..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 124..340
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 490..577
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT DOMAIN 942..1062
FT /note="Ca2+-activated K+ channel Slowpoke-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21014"
FT REGION 648..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1072..1120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..670
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1072..1102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1103..1120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1120 AA; 126520 MW; 8C7D99E561D00960 CRC64;
MSNNMDKFSP SVHMSKINVV IPYSADMLCD SNGQRMWWAF LASSMVTFFG GLFIILLWRT
LKYLWTVCCH CKAKKKEVHR ITTGEHIKRV DKDDSAASEV GWMTSVKDWA GVMISAQTLT
GRVLVVLVFA LSIGALVIYF IDSSDPIEFC KNFYSDFTLQ IDMAFNIFFL LYFGLRFIAA
NDKLWFWLEV NSVVDFFTVP PVFVSVYLNR SWLGLRFLRA LRLIQFSEIL QFLNILKTSN
SIKLVNLCSI FISTWLTAAG FIHLVENSGD PWENFQNSQA LSYWECVYLL MVTMSTVGYG
DVYAKTTLGR LFMVFFILGG LAMFASYVPE IIELIGNRKK YGGSYSAVNG RKHIVVCGHI
TLESVSNFLK DFLHKDRDDV NVEIVFLHNI SPNLELEALF KRHFTQVEFY QGSVLNPHDL
ARVKIESADA CLILANKYCA DPDAEDASNI MRVISIKNYH PKIRIITQML QYHNKAHLLN
IPSWNWKEGD DAICLAELKL GFIAQSCLAQ GLSTMLANLF SMRSFIKIEE DTWQKYYLEG
VANEMYTEYL SSAFVGLSFP VICELCYVKL KLLLIAIEYK SDQRESSTLI NPGNHVKMQE
GTLGFFIASD AKEVKRALFY CKACHDDITD PKRIKKCGCK KFEEDRQSAL SPKKKQRNGG
MRSSPNSSPK IMRHDPLLIP GSEQIESMDE NVKKYDSTGM FHWCPSRDIE KVILTRSEAA
MTVLSGHVVV CIFGDVKSAL IGLRNFVMPL RASNFHYHEL KHIVFVGSLE YLKREWETLH
NFPKVSILPG TPLSRADLRA VNINLCDMCV ILSANQNNID DASLQDKECI LASLNIKSMQ
FDDSIRVLQA NSQGFTPPGM DRSSPENSPV HGLVRQTSVT TGANIPIITE LVNDSNVQFL
DQDDDDDPDT ELYLTQPFAC GTAFAVSVLD SLMSATYFND NILTLIRTLV TGGATPELEG
LLAEENALRG GYSTPQTLAN RDRCRVAQLA LYDGPFADLG DGGCYGDLFC KALKTYNMLC
FGIYRLRDAH LNTQSQCTKR YVITNPPYAF ELVPSDLIFC LMQFDHNAGQ SRTSLSHSSH
SSHSSSKKSS SVHSIPTTNR TNRIKNRDSR DKQKKDMVYR
//
