ID   A0A3B3C2J5_ORYME        Unreviewed;       312 AA.
AC   A0A3B3C2J5;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=TSC complex subunit 2 {ECO:0000313|Ensembl:ENSOMEP00000012161.1};
GN   Name=TSC2 {ECO:0000313|Ensembl:ENSOMEP00000012161.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000012161.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000012161.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B3C2J5; -.
DR   Ensembl; ENSOMET00000032601.1; ENSOMEP00000012161.1; ENSOMEG00000013613.1.
DR   GeneTree; ENSGT00950000183139; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0033596; C:TSC1-TSC2 complex; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR   InterPro; IPR003913; Tuberin.
DR   InterPro; IPR027107; Tuberin/Ral-act_asu.
DR   InterPro; IPR024584; Tuberin_N.
DR   PANTHER; PTHR10063; TUBERIN; 1.
DR   PANTHER; PTHR10063:SF0; TUBERIN; 1.
DR   Pfam; PF11864; DUF3384; 1.
DR   PRINTS; PR01431; TUBERIN.
PE   4: Predicted;
FT   DOMAIN          99..237
FT                   /note="Tuberin N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF11864"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          274..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   312 AA;  34691 MW;  0C03A3E03E1D590F CRC64;
     MNKPQSKESL KDKVKGILGL GGPRPPSKQS DFKPSEFIIT TDIIRELHPD CGLSNRVRTM
     NHICDLAKSK KFEEVSGERG GGRVEGCRGH QTLRLHPLAY FFKVIRDYQP SNEDLSDRLE
     VFKALTENGK DITYLEEDIA RFVLLWMDIG LTSDFLHVLV NLVKFNSCYL DQNVSVMVQK
     ICLLCNRTTS STDIEVALQV LDAVVCYNCL PSESLSTFII TLCRTVNVKE FCESCWKEGP
     GNASGPQRHL HHVPYNGGEN VHGRRSAAER SGVLRGHGAV GGTPTSSSKK HPHTRAAILL
     QGHVFCQRGG FL
//