ID   A0A3B3C332_ORYME        Unreviewed;       634 AA.
AC   A0A3B3C332;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like {ECO:0000313|Ensembl:ENSOMEP00000011728.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000011728.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000011728.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-
CC         deoxyribonucleoside + H(+) + triphosphate; Xref=Rhea:RHEA:46148,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18036,
CC         ChEBI:CHEBI:18274, ChEBI:CHEBI:61560;
CC         Evidence={ECO:0000256|ARBA:ARBA00001432};
CC   -!- SIMILARITY: Belongs to the SAMHD1 family.
CC       {ECO:0000256|ARBA:ARBA00005776}.
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DR   AlphaFoldDB; A0A3B3C332; -.
DR   Ensembl; ENSOMET00000032431.1; ENSOMEP00000011728.1; ENSOMEG00000013085.1.
DR   GeneTree; ENSGT00390000013867; -.
DR   Proteomes; UP000261560; Unplaced.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 3.30.70.2760; -; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   PANTHER; PTHR11373; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE; 1.
DR   PANTHER; PTHR11373:SF4; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1; 1.
DR   Pfam; PF01966; HD; 1.
DR   SMART; SM00471; HDc; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   PROSITE; PS51831; HD; 1.
PE   3: Inferred from homology;
FT   DOMAIN          57..179
FT                   /note="HD"
FT                   /evidence="ECO:0000259|PROSITE:PS51831"
FT   REGION          156..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          557..634
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        168..189
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        557..626
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   634 AA;  72449 MW;  01BBB926F188A321 CRC64;
     MAQSRELGKV FKDSIHGHVE LHPLLVKIID TPQFQRLRNI KQLGGGYLVY PGASHNRFEH
     SLGVAYLAGV LAKTLQENQP ELKITVRDIL CVQIAGLCHD LGHGPFSHLF DQMFIDQACE
     NEDWTHEKAS LEMFRYLVHE NNLKPEMKKC GLNIKDDQED KEDDQENKKD DQEDKKDDQE
     DKKGEQEDKK DDQEDEEDDL VFIEELLGKP LKENKNVSKA DWPYKGRKVE KSFLYEIVSN
     KLNGIDVDTF DYVARDCHHL GIKNNFDHLR YFKFARVVKV DKDPRKHIGS RDKEIWNLYN
     MFHSRNLLYR EVCHHEVTNV QIMIKDALLK ANIHTMFKDK DGHLLTLSAA KDDMEAYTKV
     TDQVTEKILQ SSGEARKDSR MILERIMKRD LYKLVGEAKV RKHETILPKT IIERLKEQLK
     DDLTLEELEE IMNGTLEVVV RETQVKKYKL KGKVKDLKQQ LKTVLPSGEQ KKANDYFEAV
     PIQEVKDPIE YTYFYDKKNP QRGFTMPRNK VSNFLPECFW EQTIRLYWKK KEETYKDSTI
     EKFEKWCKDN KFEVTFNSPP NEASTSASAS TSASASTSAP ANTSASASTS APASTSAPAS
     TSASASTSAP ASTSAPASTS APANTSAPGR LDED
//