ID A0A3B3C4V9_ORYME Unreviewed; 345 AA.
AC A0A3B3C4V9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Eukaryotic elongation factor 2 lysine methyltransferase {ECO:0000313|Ensembl:ENSOMEP00000012619.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000012619.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000012619.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. EEF2KMT family. {ECO:0000256|ARBA:ARBA00005511}.
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DR AlphaFoldDB; A0A3B3C4V9; -.
DR STRING; 30732.ENSOMEP00000012619; -.
DR PaxDb; 30732-ENSOMEP00000012619; -.
DR Ensembl; ENSOMET00000020018.1; ENSOMEP00000012619.1; ENSOMEG00000014009.1.
DR GeneTree; ENSGT00940000164788; -.
DR OMA; TGFFHST; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR029426; FAM86_N.
DR InterPro; IPR019410; Methyltransf_16.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR14614; HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN; 1.
DR PANTHER; PTHR14614:SF164; PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT; 1.
DR Pfam; PF14904; FAM86; 1.
DR Pfam; PF10294; Methyltransf_16; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 30..121
FT /note="FAM86 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14904"
SQ SEQUENCE 345 AA; 37925 MW; 26F529AC699BEF01 CRC64;
MSFSETFPQW IVGTEEVNKS WRRMAQRCGE TAGILREFSA SFFAMRRVAA LPWTAVEEEL
QISGSSGLIS DLLAQTCLHP LCRKFPPSVR YRRLFLSELI KRQEVAGGDP LDELYDALAE
VLGVKETSES FRSYRLPCGA FVSLLENVAL ISGGTTGLVT WEAALYLAEW ALDRPQLFSG
RAVLELGSGV GMSGISICRG CGPRRFVFSD CHPAVLQKLR ENVRLNGLGA DSLPAVSVNQ
LDWTTATEEE LRAVGADAVI AADVVFDPDL TGSLAQLLSR VLRCRPGEVD PLVLICSTVR
NPQTYGGFKL QLEEAGLSHE VMSEPAAHVF PYDRTTPIEL LRVFR
//
