ID A0A3B3C5E1_ORYME Unreviewed; 643 AA.
AC A0A3B3C5E1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=procollagen-proline 3-dioxygenase {ECO:0000256|ARBA:ARBA00012262};
DE EC=1.14.11.7 {ECO:0000256|ARBA:ARBA00012262};
GN Name=P3H2 {ECO:0000313|Ensembl:ENSOMEP00000012297.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000012297.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000012297.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Evidence={ECO:0000256|ARBA:ARBA00001962};
CC -!- COFACTOR:
CC Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
CC Evidence={ECO:0000256|ARBA:ARBA00001961};
CC -!- SIMILARITY: Belongs to the leprecan family.
CC {ECO:0000256|ARBA:ARBA00006487}.
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DR AlphaFoldDB; A0A3B3C5E1; -.
DR Ensembl; ENSOMET00000019608.1; ENSOMEP00000012297.1; ENSOMEG00000013713.1.
DR GeneTree; ENSGT00940000159593; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0031418; F:L-ascorbic acid binding; IEA:InterPro.
DR GO; GO:0019797; F:procollagen-proline 3-dioxygenase activity; IEA:UniProtKB-EC.
DR GO; GO:0032963; P:collagen metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.620; q2cbj1_9rhob like domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR InterPro; IPR039575; P3H.
DR InterPro; IPR006620; Pro_4_hyd_alph.
DR InterPro; IPR044862; Pro_4_hyd_alph_FE2OG_OXY.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR14049; LEPRECAN 1; 1.
DR PANTHER; PTHR14049:SF1; PROLYL 3-HYDROXYLASE 2; 1.
DR Pfam; PF13640; 2OG-FeII_Oxy_3; 1.
DR SMART; SM00702; P4Hc; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 3: Inferred from homology;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..643
FT /note="procollagen-proline 3-dioxygenase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017432951"
FT DOMAIN 492..606
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
SQ SEQUENCE 643 AA; 73651 MW; 89976CBE9BBEBD66 CRC64;
MDGKPPAAVL SPALLLSAVC LCAAAADVLQ PYDLLYDHAV RAFYDSDYEE TARAMEGALR
SHAQLRRTKV RCRPKCQDQH PFDGTFSDLR FFDVVLRRSA CLVKCMEDKL GAQSRHKVSE
DVVQDFNRRI PYNYLQLAYQ KLKQPEKAAA AAHTYFQANP EHVEMGQNLE QYKVLEGVRE
QHFVDREVRP HQRCFTDAVK FYDKEDYEGA ISLFEEALVE YFQADVACRA LCQGPQKFED
HDHLRYRYSL LEVVSDHFTQ VLHCEHECVR DLATRPGRLS PMENYLPLHY DYLQFAYFKG
LLEDALQCAL TYLLFHDGEE FMTENVDFYR EVLGHDGEPR EVSTLTVQSV CYISISYLDL
RWCFYRKSDC KRCGMILAGG PLIYEGVQLV QNSGDLNGTQ RALFDHIMSE QDCEELRNLA
VTMAGDGYRG RTSPHTPNEK FEGATVLKTL QYGYEGRVPM KSARLFYNVS ERARRIVESY
FMLNSTLHFS YTHLVCRTAI TGQQDHRNDL SHPIHADNCL LDPDAHECWK EPPAYTYRDY
SALLYLNGDF DGGEFIFTEI DAKTVTASVK PKCGRMVSFS SGGENPHGVK AVTSGQRCAI
ALWFTLDPLF RELERLQADE VIQALDTQSV WSQSFSVNPK DEL
//
