ID A0A3B3C5N8_ORYME Unreviewed; 900 AA.
AC A0A3B3C5N8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=F-BAR domain only protein 2 {ECO:0000256|ARBA:ARBA00018998};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000012904.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000012904.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane, clathrin-coated pit
CC {ECO:0000256|ARBA:ARBA00004283}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004283}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004283}.
CC -!- SIMILARITY: Belongs to the FCHO family.
CC {ECO:0000256|ARBA:ARBA00011064}.
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DR AlphaFoldDB; A0A3B3C5N8; -.
DR Ensembl; ENSOMET00000032910.1; ENSOMEP00000012904.1; ENSOMEG00000014430.1.
DR GeneTree; ENSGT00940000157105; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR CDD; cd07673; F-BAR_FCHO2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.60.40.1170; Mu homology domain, subdomain B; 2.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR036168; AP2_Mu_C_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR030122; FCHo2_F-BAR.
DR InterPro; IPR028565; MHD.
DR InterPro; IPR018808; Muniscin_C.
DR PANTHER; PTHR23065:SF8; F-BAR DOMAIN ONLY PROTEIN 2; 1.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF10291; muHD; 1.
DR SMART; SM00055; FCH; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF49447; Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS51072; MHD; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 4..250
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 569..842
FT /note="MHD"
FT /evidence="ECO:0000259|PROSITE:PS51072"
FT REGION 281..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 406..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 865..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 87..208
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 291..306
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..900
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 900 AA; 98447 MW; 364A9384B5163331 CRC64;
MITPYFLENF WGEKNNGFDV LYHNMKHGQI STKELTDFIR ERSTIEEAYA RSMTKLAKTA
GNFSQLGTFA PVWDVFKSST EKQAGCHMDL ARKLQELIKE VQKYIEEQAK AHKKTKEEVA
PTLEAVQNIQ TISQSLQKSK ENYNAKTVEQ ERLRKEGATQ RDVDKAGVKA KKATEAYKSY
VEKYANAKSE FEQKMAETAQ KFQDIEENHI LQLKEIIRSY SEYVEETHVQ IGEVHKEFVR
NIENTSVESL IQKLSESKGT GKERPGPIEF EECNAAVATE GAKPRKRIPF GIPGRRKDKD
TDSTESTEVE ANNTANGAPP GYYGSIDIQN ANVPQVDAEG FCIRPEVNEN DAKDNSFYSS
SDSDDEDEPR KFHVQIKPVQ PNNGTHHNRA NIDELKASIG NIILSPSTSG QMRRNQSRLT
GVSALKPKPQ GSGDELAKSR GPTSYELTNN DLLSLDPLSP PQLGGASYAS AVPVPNRPIT
PLATGALMPP PRPSSRPKLP TAKLTGINEI GRPFSPPKTS SASPPPTAPL ARAESSSSLS
SNASLSAANT PTVGTSRGPS PVTLASQDAL PIAVAFTESV NAYFKGADPT KCIVKITGDM
TLSFPMGIIK VFTSNPSPAV LTFKLKNASR LEQILPNVQL LHSDPSQSDS DSKSFWFNMQ
ALTSYLRKSS EQNPSASYYN VDILKYQVQS DGIHSTPLNL AVYWKCTPST TDLRVDYRYN
PESMDSPGSL TNVQVLVPVD GGVTNVQSLP NSIWSSEQNK CLWKLSDLSS KSENEGAGSI
RAKFDLSNGP SNPSTLAVQF MSEGSTLSGV DMELQGSGYR LSLSKKRFAT GESHSSILQM
VDVERQKKKK KSSLCSLRAL HGGLLRKETP HSTQNAGNAS GAAAVHTGSQ NLTTKSSTEY
//
