ID A0A3B3C757_ORYME Unreviewed; 778 AA.
AC A0A3B3C757;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=AMP deaminase {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
DE EC=3.5.4.6 {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
GN Name=AMPD2 {ECO:0000313|Ensembl:ENSOMEP00000013128.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000013128.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000013128.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=AMP + H(+) + H2O = IMP + NH4(+); Xref=Rhea:RHEA:14777,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:58053, ChEBI:CHEBI:456215; EC=3.5.4.6;
CC Evidence={ECO:0000256|PIRNR:PIRNR001251};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|PIRNR:PIRNR001251};
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC from AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004955}.
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676,
CC ECO:0000256|PIRNR:PIRNR001251}.
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DR AlphaFoldDB; A0A3B3C757; -.
DR Ensembl; ENSOMET00000020695.1; ENSOMEP00000013128.1; ENSOMEG00000014615.1.
DR GeneTree; ENSGT00950000183011; -.
DR OMA; YTEILYP; -.
DR UniPathway; UPA00591; UER00663.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR CDD; cd01319; AMPD; 1.
DR Gene3D; 4.10.800.20; -; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR006650; A/AMP_deam_AS.
DR InterPro; IPR006329; AMPD.
DR InterPro; IPR032466; Metal_Hydrolase.
DR NCBIfam; TIGR01429; AMP_deaminase; 1.
DR PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR PANTHER; PTHR11359:SF3; AMP DEAMINASE 2; 1.
DR Pfam; PF19326; AMP_deaminase; 1.
DR PIRSF; PIRSF001251; AMP_deaminase_met; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR PROSITE; PS00485; A_DEAMINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PIRNR:PIRNR001251};
KW Metal-binding {ECO:0000256|PIRNR:PIRNR001251}.
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 778 AA; 90337 MW; F26269E71395DADF CRC64;
MTDDLRGVSG PKPLKPQRSL PGTPVSISHP PIDLRTSMEE KYKEIAEELF TRSMAESEMR
SAPYEFPEDS PIEQLEERRH RLERQISQDI RLMKDTSVDT VHMGFQERQM PLEREYQRVS
ISGEEKCGVP FTDLVDAAKC VVKALFIREK YIHRSLQTFC KTTAHALHDL GTKTLDLGIY
DDVPETPVDA DAPVHPPVSE THPYDDMDSM ILPPDAGYGC KMVDGVVHVF TRSYNMDKST
ELELLYPDLK EYIADMNVMM SLIINGPVKS FCYRRLQYLS SKFQMHILLN EMKELAAQKK
VPHRDFYNIR KVDTHIHASS CMNQKHLLRF IKRAMKKYQG EIVHVECGRG QTLKDVFESM
NLTAYDLSVD TLDMHADRNT FHRFDKFNSK YNPIGESILR EIFIKTDNYI EGKYFAHIVK
EVMSDLEESK YQNSELRLSI YGRSRDEWDR LAQWAVTHRV YSDNVRWLVQ VPRLFDVYHT
KKQLANFQEM LENIFMPLFE VTINPRSHPE LHLFLEHVVG FDSVDDESKP EHHIFNLDSP
LPADWTEEDN PPYSYYLYYT YANMTVLNQL RRQRGLHTFV LRPHCGEAGP IHHLVSGFML
SENISHGLLL RKAPVLQYLY YLAQVGIAMS PLSNNSLFLS YHRNPLPEYL SRGLMISLST
DDPLQFHFTK EPLMEEYSIA AQVWKLSSCD MCELARNSVL MSGFSHRAKS YWLGPNYYKE
GPESNDIRRT NVPDIRVAYR SETLTEELHL ITHAVRTEEL DSIDEEDSLT MGPVSGRR
//
