ID A0A3B3C8P1_ORYME Unreviewed; 942 AA.
AC A0A3B3C8P1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Glutamate receptor, metabotropic 5a {ECO:0000313|Ensembl:ENSOMEP00000013452.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000013452.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000013452.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR AlphaFoldDB; A0A3B3C8P1; -.
DR STRING; 30732.ENSOMEP00000013452; -.
DR PaxDb; 30732-ENSOMEP00000013452; -.
DR Ensembl; ENSOMET00000021081.1; ENSOMEP00000013452.1; ENSOMEG00000014934.1.
DR GeneTree; ENSGT01030000234595; -.
DR OMA; TYVPEHP; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15450; 7tmC_mGluR5; 1.
DR CDD; cd06374; PBP1_mGluR_groupI; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR000202; GPCR_3_mGluR5.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF165; METABOTROPIC GLUTAMATE RECEPTOR 5A; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01055; MTABOTROPC5R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170}; Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..942
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017360350"
FT TRANSMEM 587..611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 623..643
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..672
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 693..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 740..765
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 777..799
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 805..830
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 585..847
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 942 AA; 105869 MW; 54774D096927BC5E CRC64;
MVLFWGVSVL LVCDVSWLSL KEQVGVNAQS NERRVLAHIP GDIIIGALFS VHHQPPADKV
HERKCGAVRE QYGIQRVEAM MHTLDRINAD STILPNITLG CEIRDSCWHS AVALEQSIEF
IRDTLVSSDD EESQGRCTME GGSVLLQGKK PIVGLIGPGS SSVAIQVQNL LQLFNIPQIA
YSATSMDLSD KSLFKYFMRV VPSDMQQAKA MVDIVRRYSW SYVSAIHTEG NYGESGMEAF
KDMAAKEGIC IAHSDKIYSN AGEQSFDKLL QKLRGHLPKA RVVACFCEGM TVRGILMAMR
RQRLVGEFLL VGSDGWADRY DVTDGYEREA AGGITIKLKS AYVTWFDDYY LNLKPDANPR
NPWFPEFWQH RFQCRLRGHP QENTVFNRTC KSLRHQYAQD TKMGFVINAI YSMAYGLHAM
QQSLCPGYKG LCENMRPIDG RKLLDFLMKT NFTGVSGETI HFDQNGDSPG RYEIMNFKQI
GENEYSYIHV GSWDQGGLKM NDEEIWSNSS EVIQSVCSEP CQKAQIKVIR KGEVSCCWTC
TPCKENEFVF DEYTCRACIL GSWPTDDLTG CEPIPVQYVR WGDPEPIAAV VFACLGLMAT
LFVTSVFIKF WDTPVVKSSS RELCYIILAG ICLGYLCTFS LIAKPHIIYC YLQRLGIGLS
PAMSYSALVT KTNRIARILA GSKKKICTKK PRFMSACAQL VIAFLLILLQ LGIIVALLII
EPPQVIYDYP SIREVHLICN LTTLGVVAPL GYNGLLILSC TFYAFKTRNV PANFNEAKYI
AFTMYTTCII WLAFVPIYFG SNYKIITMCF SVSLSATVAL CCMFVPKVYI MLAKPEKNVR
SAFTTSTVVR MHVGDAKKAA KTGKPSSSMA NLFRRSGSTQ DNVRYGNQSL RIKEDEASLY
VRHLLYTHPS HQIWTFLSLV FVGCKLRHGS DRSVQTLFRL EH
//