ID   A0A3B3C990_ORYME        Unreviewed;       954 AA.
AC   A0A3B3C990;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Sorting nexin 13 {ECO:0000313|Ensembl:ENSOMEP00000014380.1};
GN   Name=SNX13 {ECO:0000313|Ensembl:ENSOMEP00000014380.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000014380.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000014380.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
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DR   AlphaFoldDB; A0A3B3C990; -.
DR   STRING; 30732.ENSOMEP00000014380; -.
DR   PaxDb; 30732-ENSOMEP00000014380; -.
DR   Ensembl; ENSOMET00000022261.1; ENSOMEP00000014380.1; ENSOMEG00000000399.1.
DR   GeneTree; ENSGT00950000182856; -.
DR   OMA; EWTPTNV; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043226; C:organelle; IEA:UniProt.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   GO; GO:0010667; P:negative regulation of cardiac muscle cell apoptotic process; IEA:Ensembl.
DR   GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR   CDD; cd06873; PX_SNX13; 1.
DR   CDD; cd08719; RGS_SNX13; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR003114; Phox_assoc.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR037437; SNX13_PX.
DR   InterPro; IPR037896; SNX13_RGS.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   PANTHER; PTHR22775; SORTING NEXIN; 1.
DR   PANTHER; PTHR22775:SF3; SORTING NEXIN-13; 1.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02194; PXA; 1.
DR   Pfam; PF00615; RGS; 1.
DR   SMART; SM00312; PX; 1.
DR   SMART; SM00313; PXA; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS51207; PXA; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        30..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          97..284
FT                   /note="PXA"
FT                   /evidence="ECO:0000259|PROSITE:PS51207"
FT   DOMAIN          373..513
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   DOMAIN          559..681
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
SQ   SEQUENCE   954 AA;  110668 MW;  7EA5C1D8A9A2BC3E CRC64;
     MLAEASLSIW GWGGLGVVLF FVTFGPFAIF YLAFYIFCFI GGGFAVTLLY GKINSEKHLE
     KCEHSYLPPT QPGILKTLDE MKLELKPIKI DRRLTGSSFI DEPLQQVIQF ALRDYIQYWY
     YTLSEDESFL LEIRQTLQNA LIQFSTRSKE VDWQPYFTTR LVDDFATHLR VFRKAQDRLA
     EREDKQRDIT EELVDSFFEA EVEMERKVCR DMVCTSHKDE EGFLRDLCEL LLYLLLPPGD
     FHNKNMRYFL REVLACGVLL PLINQLSDPD YINQFVIWMI RDSSCNYEAF MNILKLTDKP
     AELEAVKDKV LEELQYLRSL DTAGDDINVI KNQINSLLFV KKVCETRIQR LQSGKEVDAL
     KLAANFGKLC VIPLDHILVH NIALQFFMDF MQAAGAQAEL FFWLTVEGYR VTAQQQLEAM
     LSWQKDGKKQ PSATKGLLKA AALGVYEQYL SEKASPRVQV DKALIAKLGE KLQNDDPTPE
     IFDEIQRKVY DMMLRDERFY PAFKQSPLYV RMLAELDMLK EPSYRGSDDG EGESFNGSPT
     GSLNLSLDDY SNSCHEDFLQ LQAFISDTGV CNDHGKTYAL YTITVFRRNS DGNEDCWITY
     RRYSDFHDFH MRITEQFENL ASILKLPGKK TFNNMDRDFL EKRKKDLNAY LQLLLNPEMV
     KACPTLIPYV YDFLENKAYS KGKGEFARKI DTFVNPLRSS IKNVSTAVKS LPDSLAEGMT
     KVSDNMGRMS ERIGQDFKQS VLKVPPLVPK SDIDPEHCRV SAQLDDNVDD NIPLRVMLLL
     MDEVFDLKEK NQWLRRNIKN LLQQLIRATY GDTINRKIVD HVDYLTSPEQ VAEYVKKFRD
     SYWPNGILAE SPPRRDKSIR MRTRVAAKTS LLGIMPDELK HIIGAETTRK GILRVFDMFQ
     YQPMNRRLVY VFLEGFLETM FPQYKFPELF VKLHSRSPRI HRYNQKLKCP SSKR
//