ID A0A3B3C9I5_ORYME Unreviewed; 361 AA.
AC A0A3B3C9I5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Voltage-dependent calcium channel gamma-7 subunit {ECO:0000256|RuleBase:RU363085};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000014264.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000014264.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Regulates the activity of L-type calcium channels that
CC contain CACNA1C as pore-forming subunit (By similarity). Regulates the
CC trafficking and gating properties of AMPA-selective glutamate receptors
CC (AMPARs). Promotes their targeting to the cell membrane and synapses
CC and modulates their gating properties by slowing their rates of
CC activation, deactivation and desensitization and by mediating their
CC resensitization. Shows specificity only for GRIA1 and GRIA2.
CC {ECO:0000256|RuleBase:RU363085}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU363085}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363085}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC {ECO:0000256|ARBA:ARBA00007111, ECO:0000256|RuleBase:RU363085}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU363085}.
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DR AlphaFoldDB; A0A3B3C9I5; -.
DR STRING; 30732.ENSOMEP00000014264; -.
DR PaxDb; 30732-ENSOMEP00000014264; -.
DR Ensembl; ENSOMET00000022321.1; ENSOMEP00000014264.1; ENSOMEG00000015745.1.
DR GeneTree; ENSGT01050000244961; -.
DR OMA; SYPHTLH; -.
DR OrthoDB; 2957055at2759; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.140.150; -; 1.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR008371; VDCC_g7su.
DR InterPro; IPR008368; VDCC_gsu.
DR PANTHER; PTHR12107; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT; 1.
DR PANTHER; PTHR12107:SF12; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-7 SUBUNIT; 1.
DR Pfam; PF13903; Claudin_2; 1.
DR PRINTS; PR01792; VDCCGAMMA.
DR PRINTS; PR01795; VDCCGAMMA7.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|RuleBase:RU363085};
KW Calcium channel {ECO:0000256|RuleBase:RU363085};
KW Calcium transport {ECO:0000256|RuleBase:RU363085};
KW Ion channel {ECO:0000256|RuleBase:RU363085};
KW Ion transport {ECO:0000256|RuleBase:RU363085};
KW Membrane {ECO:0000256|RuleBase:RU363085};
KW Transmembrane {ECO:0000256|RuleBase:RU363085};
KW Transmembrane helix {ECO:0000256|RuleBase:RU363085};
KW Transport {ECO:0000256|RuleBase:RU363085};
KW Voltage-gated channel {ECO:0000256|RuleBase:RU363085}.
FT TRANSMEM 103..122
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
FT TRANSMEM 129..155
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
FT TRANSMEM 175..201
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
FT REGION 235..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..350
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 361 AA; 39487 MW; 859E972EE7FA16E2 CRC64;
MSSFSTRALT LLSSVFGACG LLLVGVAVST DYWLLMEEGI VLQQNQTTEV KMALHSGLWR
VCFVAGPEKG RCVASEYFTE PEIEITTENT ANILKMVRTA TPFPMVSLLF VFTAFVISNI
GHIRPQRTIL AFVSGIFFIL SGLSLVVGLV LYISSINDEV MNRPREAEQF FHYHYGWSFA
FAASSFLLKE GAGVMSVYLF MKRYAEEELY RPHPALYRPR MSDCSDYSGQ FLHPDSWAPP
QRGRSASDVS SDISIQLNQT PPPQQHLKGG SSSQATPSSS GPSSAASYQL HPASSSSTSS
SYPHPLHPGA TSTLTRASHA HDHFQHHPHP SGPPPQSLPM AAPPSAVPPP RYHTRMSASP
C
//
