UniProt: A0A3B3CA11

Database: UniProt
Entry: A0A3B3CA11_ORYME

LinkDB:  A0A3B3CA11_ORYME 
Original site:  A0A3B3CA11_ORYME

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Ontology (5)   
   GO (5)   
Gene (3)   
   ENSEMBL-UP (3)   
Protein domain (21)   
   InterPro (11)   
   Pfam (5)   
   PROSITE (3)   
   SMART (2)   
All databases (29)   

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ID   A0A3B3CA11_ORYME        Unreviewed;      1183 AA.
AC   A0A3B3CA11;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Integrin subunit alpha 2 {ECO:0000313|Ensembl:ENSOMEP00000014650.1};
GN   Name=ITGA2 {ECO:0000313|Ensembl:ENSOMEP00000014650.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000014650.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000014650.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC       ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC   -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC       {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR   AlphaFoldDB; A0A3B3CA11; -.
DR   STRING; 30732.ENSOMEP00000014650; -.
DR   PaxDb; 30732-ENSOMEP00000014650; -.
DR   Ensembl; ENSOMET00000022603.1; ENSOMEP00000014650.1; ENSOMEG00000016166.1.
DR   GeneTree; ENSGT00940000156303; -.
DR   OMA; IQYASQW; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0009986; C:cell surface; IEA:UniProt.
DR   GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR   Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR   Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR   Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR   Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013517; FG-GAP.
DR   InterPro; IPR013519; Int_alpha_beta-p.
DR   InterPro; IPR000413; Integrin_alpha.
DR   InterPro; IPR018184; Integrin_alpha_C_CS.
DR   InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR   InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR   InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR   InterPro; IPR028994; Integrin_alpha_N.
DR   InterPro; IPR032695; Integrin_dom_sf.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR   PANTHER; PTHR23220:SF23; INTEGRIN ALPHA-2; 1.
DR   Pfam; PF01839; FG-GAP; 2.
DR   Pfam; PF08441; Integrin_A_Ig_1; 1.
DR   Pfam; PF20805; Integrin_A_Ig_2; 1.
DR   Pfam; PF20806; Integrin_A_Ig_3; 1.
DR   Pfam; PF00092; VWA; 1.
DR   PRINTS; PR01185; INTEGRINA.
DR   PRINTS; PR00453; VWFADOMAIN.
DR   SMART; SM00191; Int_alpha; 5.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR   SUPFAM; SSF69179; Integrin domains; 3.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51470; FG_GAP; 4.
DR   PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW   ECO:0000256|RuleBase:RU003762};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003762};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU003762}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT   CHAIN           17..1183
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT                   /id="PRO_5017105170"
FT   TRANSMEM        1131..1153
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT   REPEAT          29..87
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   DOMAIN          167..350
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REPEAT          470..532
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          533..591
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          595..655
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ   SEQUENCE   1183 AA;  128811 MW;  715F300907EF7448 CRC64;
     MGVFWGSFCF VVIVFTDRIC VLDSFNVGTA DAKIFSGSAS EEFGYTVQQA TNSDGKWLLV
     GAPWSGYSKN RKGDVYKCPV SGSTNSCAKL SFQDLVKIPD VTNINVNMSL GLTLTPMNAG
     LLTCGPLWGQ QCGDQNFYPG VCAKLDATFK LQSAFSDAVQ KCGGPMDIVI VLDGSNSIYP
     WEPMRDFVLK LIPSLDIGPQ STQVSVIQYA ISSEFVIRMN EYESKEQLLA AASKITQMSG
     TMTNTFHAIE FASQWGFNEI YGGRPGASKV MVVVTDGESH DVNKREAVIA ECERKGITRF
     GIAVLGYYIR NNFDTGKLIE EIKSIASFPT ENFFFNVSEE AALSSITGTL GNRIFNIEGT
     GKGADNFQME MSQVGFSAHY SSKQNVTMLG AVGAYAWSGT VIHHAETNVN ILPSSAFERA
     LQDRNHSSLL GYSVTTISDG SAEFFVAGAP RSNHSGQVLV YTINAQKQAS VIDSQRGKQI
     GSYFGSVLCP LDLDIDGVTD LLLVGAPMYM GELKKEEGRV YLFSVNRGFL NEQGFLSGPP
     PTANSRFGTA ISVIPDLDLD GYSDVVVGAP LEDGGRGVVY IYNGEKKTLK KEFSQRIVGS
     KLDAQLQYFG RALDSTKDLN GDSIPDISIG AYGKVVQLWS RGVASVTASA SFNPDKINIF
     NKQCNIKGRM LTCFDTELCL TASFKPKNPT GQIGIFYTLT LDASLQDSRV TSRGMFTKTN
     ERYIKEKAQI SSTPLCQHFE VYVQETPDFV NSLSLKVEVE QQNADGNPVL DIFSPSAFHF
     FIPFTKDCGS DEVCMSDLVL SVKTDTKTSS SGPTLVGANN QDLSFDVSVK NKQENAYNTR
     VSVKYSDNLF YSTFSAAEGV QCTSTQADVV TCQVGYPVLK KDQEVKFSIK FNYNLNQLQN
     KAEVTFQAKS DGGEENPADN DALKSVSLQY DTGIVLSRQS NINFYVADTT SQVVSTVESV
     DDIGPEFNFT VKVSTGSVPV SLLYLTIGLP VETNGGNPLL YLIDVKPQGG GSVNCDSSQL
     IDPLKIAEKK KRSVSFTEES LRGMEKLDCK SAKCANIKCI LKDTRVLTHY FVEVKTRIWN
     GTFMTATYQT IELTSSLDVE TTDPNLLVIG LKQLPVTLTI SKPGETADVP VGVIAGSAIA
     GVLLLALVVG VLYKVGFFKR KYQQLQKEAD DDEQSQAHPN EVL
//

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