ID A0A3B3CBA4_ORYME Unreviewed; 631 AA.
AC A0A3B3CBA4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Rac GTPase-activating protein 1-like {ECO:0000313|Ensembl:ENSOMEP00000014889.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000014889.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000014889.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3CBA4; -.
DR Ensembl; ENSOMET00000033756.1; ENSOMEP00000014889.1; ENSOMEG00000016435.1.
DR GeneTree; ENSGT00940000154610; -.
DR OMA; CRKKWLR; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd20821; C1_MgcRacGAP; 1.
DR CDD; cd04382; RhoGAP_MgcRacGAP; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR46199; RAC GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR46199:SF1; RAC GTPASE-ACTIVATING PROTEIN 1; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 294..343
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 357..547
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 182..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 58..106
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 260..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 579..631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 631 AA; 70175 MW; 7A9CBAB5314E9DE3 CRC64;
MESSGMNLNN QFQSLRAQVE ALNDSVEPQF LQMAVHFEEC RKKWLLAGDE LVSCKEMLAK
AETERGALEV RLKHARNQVD VEIRRRQKAE AVHEKLERQL QLIRDLLVSE NNGSSVHLSE
EQRSALAFLS AHSQAAQGAK TNLNGSRRLT RIEESGSLLS DISYDQTDES LDWDSSVMKN
VRLRKRQKRR SSRKHSEGPP LAAKKSRSTG RASEKVNESI VAKTTITTNG AVVEAVSTIE
AVPYWTRGRK RSEALLFGQT NTTDQSESAS EVSGTLAPSL TGPPKPLRAR AGKKHNFIAK
TVIKSEFCGP CGRRTKFGKL YLRCQDCRVV AHPECRDLCP LPCNPPAVAT PIRTTEATLA
DFAPPTAPMI PALVIFCVKE IERRGLREVG LYRVSGHERA VKELKEKLVR GKTLPLLNKV
EDINVIAGVL KDFLRNLPEP LLTFHLNKVF MEAAEIQDDG NCLATLYQTI SELPQPNRDT
LAFLMIHLHK VAQSVDTKMD VKNLARVFGP TLVGHAVPDP DPMTILHDTS RQPKVVELLM
SMPQSYWSRF AYPDVTDMDS SQQPDSPKHK VSILGPVTTP EHQMISKTPS SSSLSQRMMQ
TLSSTSFFGS KSKAASAPNR QGNFFTSPQL K
//
