ID A0A3B3CBK7_ORYME Unreviewed; 879 AA.
AC A0A3B3CBK7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN Name=CLCN3 {ECO:0000313|Ensembl:ENSOMEP00000015195.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000015195.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000015195.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Early
CC endosome membrane {ECO:0000256|ARBA:ARBA00004520}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004520}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004107}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004107}. Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004155}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family. ClC-
CC 3/CLCN3 subfamily. {ECO:0000256|ARBA:ARBA00008934}.
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DR AlphaFoldDB; A0A3B3CBK7; -.
DR STRING; 30732.ENSOMEP00000015195; -.
DR PaxDb; 30732-ENSOMEP00000015195; -.
DR Ensembl; ENSOMET00000023292.1; ENSOMEP00000015195.1; ENSOMEG00000016743.1.
DR GeneTree; ENSGT00940000153763; -.
DR OrthoDB; 150430at2759; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03684; ClC_3_like; 1.
DR Gene3D; 3.90.1280.20; -; 2.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR InterPro; IPR002245; Cl_channel-3.
DR PANTHER; PTHR45711; CHLORIDE CHANNEL PROTEIN; 1.
DR PANTHER; PTHR45711:SF8; H(+)_CL(-) EXCHANGE TRANSPORTER 3; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR PRINTS; PR01114; CLCHANNEL3.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 2.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703};
KW Chloride {ECO:0000256|ARBA:ARBA00023214, ECO:0000256|RuleBase:RU361221};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 216..238
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 258..279
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 286..303
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 315..339
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 388..410
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 430..449
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 501..522
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 534..555
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 575..600
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 660..726
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 757..814
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 879 AA; 98004 MW; 02E611262362AD1A CRC64;
MESEQLYHRG YCRNSYNSIA SASSDEELLD GAGVIMDFHT TEDDNLLDGD AASPGSNYAM
SNGGGAASST THLLDFLEEP IPGVGTYDDF HTIDWVREKC KDRERHRKVN SKKKESAWEF
TKSLYDAWSG WLVVTLTGLA SGALAGLIDI AADWMNDLKE GVCLSAMWFN HEQCCWTSNE
TTFAERDKCP QWKSWAELIL GQAEGPGSYI MNYFMYIYWA LSFAFLAVCL VKVFAPYACG
SGIPEIKTIL SGFIIRGYLG KWTLMIKTIT LVLAVASGLS LGKEGPLVHV ACCCGNIFSY
LFPKYSKNEA KKREVLSAAS AAGVSVAFGA PIGGVLFSLE EVSYYFPLKT LWRSFFAALV
AAFVLRSINP FGNSRLVLFY VEYHTPWYLF ELIPFILLGV FGGLWGAFFI RANIAWCRRR
KSTRFGKYPV LEVILVAAIT AVVAFPNPYT RQNTSELIKE LFTDCGPLET SQLCKYRSQM
NGSKAFTDDP NQPAEPGVYS AMWQLCLALI FKIIMTIFTF GLKVPSGLFI PSMAIGAIAG
RIVGIAVEQL AYYHHDWFLF KEWCEVGADC ITPGLYAMVG AAACLGGVTR MTVSLVVIVF
ELTGGLEYIV PLMAAVMTSK WVGDAFGREG IYEAHIRLNG YPFLDAKEEF THTTLAREVM
RPRRNDPPLA VLTQDDLTVE ELQSVINETS YNGFPVIVSK ESQRLVGFAL RRDITIAIEN
ARRKQEGILL NSRVYFTQHA PSLPADSPRP LKLRSILDMS PFTVTDHTPM EIVVDIFRKL
GLRQCLVTHN GIVLGIITKK NILEHLEELK QHTEPLATSW YYHKKRHPPS HGANGKPRSR
VHHVQLIRSF QDGWGRGGEG SDEEDEEEEV VCLLNGSNL
//
