ID A0A3B3CC89_ORYME Unreviewed; 550 AA.
AC A0A3B3CC89;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Vitronectin {ECO:0000313|EMBL:KAF6736016.1, ECO:0000313|Ensembl:ENSOMEP00000015430.1};
GN ORFNames=FQA47_014530 {ECO:0000313|EMBL:KAF6736016.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000015430.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000015430.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|EMBL:KAF6736016.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bigg-433 {ECO:0000313|EMBL:KAF6736016.1};
RX PubMed=32938378;
RA Liang P., Saqib H.S.A., Ni X., Shen Y.;
RT "Long-read sequencing and de novo genome assembly of marine medaka (Oryzias
RT melastigma).";
RL BMC Genomics 21:0-0(0).
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DR EMBL; WKFB01000097; KAF6736016.1; -; Genomic_DNA.
DR STRING; 30732.ENSOMEP00000015430; -.
DR PaxDb; 30732-ENSOMEP00000015430; -.
DR Ensembl; ENSOMET00000023599.1; ENSOMEP00000015430.1; ENSOMEG00000017015.1.
DR GeneTree; ENSGT00530000063751; -.
DR OMA; LGTYNYD; -.
DR OrthoDB; 5310951at2759; -.
DR Proteomes; UP000261560; Unplaced.
DR Proteomes; UP000646548; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0030247; F:polysaccharide binding; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd00094; HX; 1.
DR Gene3D; 4.10.410.20; -; 1.
DR Gene3D; 2.110.10.10; Hemopexin-like domain; 2.
DR InterPro; IPR000585; Hemopexin-like_dom.
DR InterPro; IPR036375; Hemopexin-like_dom_sf.
DR InterPro; IPR018487; Hemopexin-like_repeat.
DR InterPro; IPR020436; SMB_chordata.
DR InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR PANTHER; PTHR22917; HEMOPEXIN DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22917:SF7; VITRONECTIN A; 1.
DR Pfam; PF00045; Hemopexin; 3.
DR Pfam; PF01033; Somatomedin_B; 1.
DR PRINTS; PR00022; SOMATOMEDINB.
DR SMART; SM00120; HX; 4.
DR SMART; SM00201; SO; 1.
DR SUPFAM; SSF50923; Hemopexin-like domain; 2.
DR SUPFAM; SSF90188; Somatomedin B domain; 1.
DR PROSITE; PS51642; HEMOPEXIN_2; 4.
DR PROSITE; PS00524; SMB_1; 1.
DR PROSITE; PS50958; SMB_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000646548};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..550
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040680326"
FT DOMAIN 18..60
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT REPEAT 177..221
FT /note="Hemopexin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT REPEAT 222..269
FT /note="Hemopexin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT REPEAT 270..322
FT /note="Hemopexin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT REPEAT 489..541
FT /note="Hemopexin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT REGION 77..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 550 AA; 64492 MW; 848E5EAAA3E69DCE CRC64;
MKLWAILLFS LLIAAFAEDE SCLDRCENGF DSRRTCQCDS MCKYYKSCCF DFEAVCGMTT
RGDTFDFAED EDALFESTTP AAQTPSEKQP FTVQSRERKP SRRPDFNRSP YQRPEATLQM
TRPPRLMDEK VTPFPITEMG AITTKAPEPN ATTETTTVPT TTATTPAPDP DAEVCSGRPF
DSFMQLKNGS IYAFRGEYFF ELNQRSVLPG YPKLIKDVWG ISGPIDAAFT RINCQGKTYI
FKGNKYWRFD NGVLDDDYPR DISVGFDKIP DHVDAAFALP APHHHGKEKV YFFKGDQYYM
YEFLHQPSHE ECVTMSEHSP SALFRRYTDM YYHNFERYFS ELFSDMPQHH DKHHFINKDW
KGLKSPVDAA MAGRIYVNPR GLMPRRHDYQ PDQQWGRQQG QQWGQQYQQN GWQWGRRRSN
RSPNWGAERG MSMGQGFAER GMELGLRLAE RRMEMEERLG RDWDRRWDQD WDQDRRRDLY
NQNNRGNYDS RDDRLFQTDM PIQNVYFFKG DKYFRVDLRT KRVDPAMPPY PRSIAKYWLG
CSDTPGLEKK
//
