ID A0A3B3CEJ5_ORYME Unreviewed; 779 AA.
AC A0A3B3CEJ5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Chloride anion exchanger {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Solute carrier family 26 member 3 {ECO:0000256|RuleBase:RU362052};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000015472.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000015472.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Mediates chloride-bicarbonate exchange with a chloride
CC bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a
CC role in the chloride and bicarbonate homeostasis during sperm
CC epididymal maturation and capacitation.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
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DR AlphaFoldDB; A0A3B3CEJ5; -.
DR Ensembl; ENSOMET00000023639.1; ENSOMEP00000015472.1; ENSOMEG00000017087.1.
DR GeneTree; ENSGT01070000253775; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0098661; P:inorganic anion transmembrane transport; IEA:UniProtKB-UniRule.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF19; CHLORIDE ANION EXCHANGER; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU362052};
KW Chloride {ECO:0000256|RuleBase:RU362052};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 73..94
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 100..118
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 250..267
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 279..298
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 334..354
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 366..383
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 403..424
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 460..485
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 516..709
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
SQ SEQUENCE 779 AA; 86493 MW; BF5A7FFC3B103FF2 CRC64;
MMRPGARQYV VNRPLYSEDS FADEHEKVCR RRKTMLDHIK LYFTCDAKRA KNAALSLLPV
IGWMRIYRVK EWLLPDVVSG ISTGLVAVLQ GMAYCLLASL PPWYGLFSAF FPVIIYFFMG
TSRHISVGPF SVLCLMIGSV VTRIIPDEGP PVNITGLEGL SIDDQRVLVA SSLSFLVGIM
QLGMGLLQVG FVVMYLSDTL VSGFTTAAAI HILVSQLKFV LGLQVPGFSG PLSLIYTLEV
IFNKITSTNL CDLVISLVIM VIVFIVKEVN DRFKSKLPVP IPIEVIMTVI ACGLSYGFDF
ENKFGIDIVG HIPQGYESPV APNLQIFQET AMDAFPMAIV GFAVAFSVAK VYSVKHDYTV
DGNQELIAFG VSNMFGATFK SFVASTALSR SAVQESTGGK TQVAGLLSAI IVMIVTLAIG
FLLAPLPKSV LGAVVIANLK GMLMQFTDIP YLWRRDKPDC VVWLCTCTAS ILLGLDLGLA
VGLGVELISV VLRVQFPRCS LLANIKGTDI YKDRKDYLSI YEPEGVKIFR IPSPIFFANI
DFFRNKLVES LGFNPLQILK KRNTALRRIK KLLKNGDLQW TSMGFLNTTC GPIEDSEDKD
NMEELDQPID FKDLPARIDW NRDLPANIFV PRVDVHSLIL DFAAVSFLDI SALKGLKTML
KELIRIDIEV YIVACDPYIL EKLHDCCFFD DEVQPSMFFL TLHDAMLNVM EKHYDLTEKK
SDHGKVKQTH PLEWKRILCN LSLSASPLSP HLSRCGQTQV GPLQKLQTNL TGAHILCPL
//