GenomeNet

Database: UniProt
Entry: A0A3B3CEJ5_ORYME
LinkDB: A0A3B3CEJ5_ORYME
Original site: A0A3B3CEJ5_ORYME 
ID   A0A3B3CEJ5_ORYME        Unreviewed;       779 AA.
AC   A0A3B3CEJ5;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Chloride anion exchanger {ECO:0000256|RuleBase:RU362052};
DE   AltName: Full=Solute carrier family 26 member 3 {ECO:0000256|RuleBase:RU362052};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000015472.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000015472.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Mediates chloride-bicarbonate exchange with a chloride
CC       bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a
CC       role in the chloride and bicarbonate homeostasis during sperm
CC       epididymal maturation and capacitation.
CC       {ECO:0000256|RuleBase:RU362052}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000256|RuleBase:RU362052}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3B3CEJ5; -.
DR   Ensembl; ENSOMET00000023639.1; ENSOMEP00000015472.1; ENSOMEG00000017087.1.
DR   GeneTree; ENSGT01070000253775; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0098661; P:inorganic anion transmembrane transport; IEA:UniProtKB-UniRule.
DR   CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR   Gene3D; 3.30.750.24; STAS domain; 1.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   NCBIfam; TIGR00815; sulP; 1.
DR   PANTHER; PTHR11814:SF19; CHLORIDE ANION EXCHANGER; 1.
DR   PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR   Pfam; PF01740; STAS; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   SUPFAM; SSF52091; SpoIIaa-like; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|RuleBase:RU362052};
KW   Chloride {ECO:0000256|RuleBase:RU362052};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362052};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT   TRANSMEM        73..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        100..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        250..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        279..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        334..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        366..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        403..424
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        460..485
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   DOMAIN          516..709
FT                   /note="STAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50801"
SQ   SEQUENCE   779 AA;  86493 MW;  BF5A7FFC3B103FF2 CRC64;
     MMRPGARQYV VNRPLYSEDS FADEHEKVCR RRKTMLDHIK LYFTCDAKRA KNAALSLLPV
     IGWMRIYRVK EWLLPDVVSG ISTGLVAVLQ GMAYCLLASL PPWYGLFSAF FPVIIYFFMG
     TSRHISVGPF SVLCLMIGSV VTRIIPDEGP PVNITGLEGL SIDDQRVLVA SSLSFLVGIM
     QLGMGLLQVG FVVMYLSDTL VSGFTTAAAI HILVSQLKFV LGLQVPGFSG PLSLIYTLEV
     IFNKITSTNL CDLVISLVIM VIVFIVKEVN DRFKSKLPVP IPIEVIMTVI ACGLSYGFDF
     ENKFGIDIVG HIPQGYESPV APNLQIFQET AMDAFPMAIV GFAVAFSVAK VYSVKHDYTV
     DGNQELIAFG VSNMFGATFK SFVASTALSR SAVQESTGGK TQVAGLLSAI IVMIVTLAIG
     FLLAPLPKSV LGAVVIANLK GMLMQFTDIP YLWRRDKPDC VVWLCTCTAS ILLGLDLGLA
     VGLGVELISV VLRVQFPRCS LLANIKGTDI YKDRKDYLSI YEPEGVKIFR IPSPIFFANI
     DFFRNKLVES LGFNPLQILK KRNTALRRIK KLLKNGDLQW TSMGFLNTTC GPIEDSEDKD
     NMEELDQPID FKDLPARIDW NRDLPANIFV PRVDVHSLIL DFAAVSFLDI SALKGLKTML
     KELIRIDIEV YIVACDPYIL EKLHDCCFFD DEVQPSMFFL TLHDAMLNVM EKHYDLTEKK
     SDHGKVKQTH PLEWKRILCN LSLSASPLSP HLSRCGQTQV GPLQKLQTNL TGAHILCPL
//
DBGET integrated database retrieval system