ID   A0A3B3CFF4_ORYME        Unreviewed;       695 AA.
AC   A0A3B3CFF4;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   RecName: Full=Alpha-macroglobulin receptor-binding domain-containing protein {ECO:0000259|SMART:SM01361};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000016561.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000016561.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3B3CFF4; -.
DR   Ensembl; ENSOMET00000025059.1; ENSOMEP00000016561.1; ENSOMEG00000018306.1.
DR   GeneTree; ENSGT00940000166660; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   CDD; cd02897; A2M_2; 1.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.60.120.1540; -; 1.
DR   Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR   InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR   InterPro; IPR041813; A2M_TED.
DR   InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR   InterPro; IPR011626; Alpha-macroglobulin_TED.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR019742; MacrogloblnA2_CS.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR11412:SF160; ALPHA-2-MACROGLOBULIN-LIKE PROTEIN 1; 1.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   Pfam; PF07677; A2M_recep; 1.
DR   Pfam; PF07678; TED_complement; 1.
DR   SMART; SM01361; A2M_recep; 1.
DR   SMART; SM01419; Thiol-ester_cl; 1.
DR   SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR   PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE   4: Predicted;
FT   DOMAIN          600..689
FT                   /note="Alpha-macroglobulin receptor-binding"
FT                   /evidence="ECO:0000259|SMART:SM01361"
SQ   SEQUENCE   695 AA;  76188 MW;  294C1ACB626C5251 CRC64;
     RLTAGNRETL CALIQTPTEP VTLTITLDLD SSSTKIGELS LKSETYRCFQ FMVPMVSSAT
     VASISVKIQG RVDSLNQDTK VLIEPPAFIH IVQTDKPIYK PGQTVCVCVP RRARPSPGSE
     TTLSLKLRKL HLFVPTGDVS LKVSAEAERS NKRCGNEKVT VPTEGRIDTV ITNLLVEAEG
     VPQMISHNAL LCPKISLELP EKFVTGSERA SVSVLGDLMG RAMKNLDKLL AMPYGCGEQN
     MLLFAPNIFI LDYLKSTGQL KDSTLKTAVG YLESGYQREL NYKHDDGSYS AFGMSDASGN
     TWLTTFVMKS FNAAKAYIFV DQKYVQEART WLSGLQKPDG CIQSVGKLFH NGMKGGVSDD
     VSLTAYVAAA MLELDGNASN PVVQKCLKCL KTAAANKITN LYTVALMSYT FTLAGDKDMR
     SKLITQLDQK STNEGKTKDF QEATTYLDSV EVEMTSYVLL ALLSGPSLPR FGLDYAAGIV
     RWLAQQQNPF GGFSSTQDTV VALQALAKYA SATYSPEGST TVTVTSAGGL NKRFTVNKEN
     RLLYQEEKLS EIPGEYTIKA EGQSCVLAQI SLFYNIPPPS DFSGSAGFDS CRFQGRREET
     NMVVINIKLL SGYILQDDSL KMPRSLVVHE ASGYSGFTCT IVCILQLKKG QKETFDVTLE
     EDQQVENLKP AVVKVYDYYQ TSDQAVTDYN SPCKK
//