ID A0A3B3CI66_ORYME Unreviewed; 1082 AA.
AC A0A3B3CI66;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000016779.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000016779.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
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DR AlphaFoldDB; A0A3B3CI66; -.
DR Ensembl; ENSOMET00000025332.1; ENSOMEP00000016779.1; ENSOMEG00000018477.1.
DR GeneTree; ENSGT00940000165368; -.
DR OrthoDB; 5399547at2759; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 5.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF3; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1082
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017316805"
FT TRANSMEM 716..740
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 51..138
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 220..308
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 474..558
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 786..1045
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 963..1036
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 27..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1082 AA; 121122 MW; 64BFC2280D9D5679 CRC64;
MKLISFKADR LLLCVIFNLL WVVSDGTTTS PTSTGSSLTT TSLMTTPKPK PPDPTNFKSV
GQNESSISLE WSKVEDISTY RLEYEGNVRD VSEPDDTTIS YTLTGLSSGN RYNITLFSVR
DGDQSNGISI IAVTAPTDTE LFTNQTQNET SITLTWKRVE NISNYILFIN GKEKNIPQES
KEYIAHVVED LTSGTRHEFS LFTVFVNVHS RGNNITAVTA PTNAEKFTHL NQTETSITLT
WISEKDIFNY ILQTNGKEES IPEQSTGSVN HVVPNLTPGT RYQFRLFTVF DGVRSTGDDI
IAVTAPNNVE TFDHINQNET SITLNWTTKN DFNYTLELDG KQENFTQQST GSIKHVVRNL
INGTEYEFKL FTVFDYARSS GKTLTAVTAP ANAADFMNKT QSENSITLTW TPVNKFNYTL
IVNGKEKENF TQPSSDLKEY VVGDLTSGTE HEFRLFTVFK YARSSGEDIT AVTVPSKLNS
VKVTERTENS IIIQWISPNE KWSYEVQING SDVASSSTSA TVTDLLPGTK YVLSVISQFS
GFSSAASETI TVTKINSTAA KWEVTNSSIT ATIQGLFSRG TAVPKSQIRE SVNAQISGTN
VSFSGLIPGE TYDISLFYEI DLLQYTDSLT LIPPTLSPQC KHRGGYSVRV FWEEVPGVWT
SVKINIAGND LTVQKSETEL QIDQLQPAKT YKGSLVSMSG SRQSERVEFY CSTDPAGVIA
GSVIGVLCFF VLVVLVLIFL KKPELIRRKK PFTDGSKQIS TKETNISSTK FPDHFHQMSL
DENRGFGQEY EDLSPVGRDQ ARRAALLPDN APKNRFTNVY PYDWCRVKLN SSGPSETLNY
INASYLPGYK NNREYIATQG PLPGTVKDFW RMIWEQKVKR IAMVTNCVEG GRTKCERYWP
ENGNPGIYGE ISVTVRTEKK ETNWTLRDFI VKNMKTSEER TVKHFHFTAW PDHGVPESTD
VLIQFRGLIR QHIDSDGSNA PTVVHCSAGV GRTGTLIALD VLLQQLDKEK AVGVKYFVKK
MRFSRPYMVQ TESQYVFLHQ CIMDSLMFNT NNDDNFYENV GAVYVNATAL RELSQAQDNH
KN
//
