ID   A0A3B3CIX1_ORYME        Unreviewed;       163 AA.
AC   A0A3B3CIX1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Gremlin-1 {ECO:0000256|ARBA:ARBA00040888};
GN   Name=GREM1 {ECO:0000313|Ensembl:ENSOMEP00000017290.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000017290.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000017290.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the DAN family. {ECO:0000256|ARBA:ARBA00007872}.
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DR   AlphaFoldDB; A0A3B3CIX1; -.
DR   STRING; 30732.ENSOMEP00000017290; -.
DR   PaxDb; 30732-ENSOMEP00000017290; -.
DR   Ensembl; ENSOMET00000025995.1; ENSOMEP00000017290.1; ENSOMEG00000018966.1.
DR   GeneTree; ENSGT00940000154209; -.
DR   OMA; TIHEDGC; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR004133; DAN.
DR   InterPro; IPR017159; Gremlin-1/2.
DR   PANTHER; PTHR15283; GREMLIN 1; 1.
DR   PANTHER; PTHR15283:SF3; GREMLIN-1; 1.
DR   Pfam; PF03045; DAN; 1.
DR   PIRSF; PIRSF037254; Gremlin_precursor; 1.
DR   SMART; SM00041; CT; 1.
PE   3: Inferred from homology;
KW   Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR037254-1};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180}.
FT   DOMAIN          75..162
FT                   /note="CTCK"
FT                   /evidence="ECO:0000259|SMART:SM00041"
FT   REGION          1..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..44
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        73..123
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037254-1"
FT   DISULFID        87..137
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037254-1"
FT   DISULFID        97..155
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037254-1"
FT   DISULFID        101..157
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037254-1"
SQ   SEQUENCE   163 AA;  18767 MW;  F0B41A9E5C28A120 CRC64;
     MTKQSKRNRG SQGAIPHPDK NNPNESEQQP QPSQAGSGSR QKPGASSPAD EVLESSQEAL
     HVTERQYLKR DWCKTQPLKQ TIHEEGCVSR TIINRFCYGQ CNSFYIPRHI RREEGAFQSC
     SFCKPKRFTT MTFTLNCPDQ QPPRKRKRIQ RVKQCRCISI DLD
//