ID A0A3B3CJU0_ORYME Unreviewed; 1053 AA.
AC A0A3B3CJU0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000017856.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000017856.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR AlphaFoldDB; A0A3B3CJU0; -.
DR STRING; 30732.ENSOMEP00000017856; -.
DR PaxDb; 30732-ENSOMEP00000017856; -.
DR Ensembl; ENSOMET00000026677.1; ENSOMEP00000017856.1; ENSOMEG00000019560.1.
DR GeneTree; ENSGT00940000158480; -.
DR OMA; HITLMNV; -.
DR OrthoDB; 5488182at2759; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17974; DEXHc_DHX16; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 421..585
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 610..783
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 91..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1032..1053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..132
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..243
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1053 AA; 121302 MW; 6D14461F46624461 CRC64;
MAGLEQWVND RLHDILGLSD RYVSQFMIGI ARKSSSPEDF VSRLEQTGTI DIDQSVASFA
KELFDKIPRK QVAEKPARAI ERQALEMQRK NQTYTLLEDS DSGEDAAREE QKGKKNSKNK
DRGGKRKHIR QKKYIESSSE DEAPKRGKSS PDDQKSVKKE EEEEEWEKEE RERLQDIEER
DAFAERVRQK DKDKTRNITE RTDKKAYEEA QKRLKMAEDD QKNMLPELRK KSRQSYLKKR
EEEKLEDLEA EIKDEEYFFS LDELTERERR DLEHKRILRD LAKDYKKAGA KEQEERKNRY
YMPEEKRRKD VPERDLELEE TPMELGGEQG RWEEERLKTA SLSFGAKKER EQGMRAEQEK
YQLILEEEEM IDFVTTAITM KGTRSEKDQE AQALSQAELK KQSMQEVRRS LPIFPYREDL
LAAINEHQVL VIEGETGSGK TTQIPQYLME EGYTQGGMKI GCTQPRRVAA MSVAARVAEE
ISVKLGNEVG YSIRFEDCTS ERTVLKYMTD GMLLREFLTE PDLASYSVIL IDEAHERTLH
TDILFGLIKD IARFRPDLKV LVASATLDTE RFSSFFDDAP VFRIPGRRFP VDIFYTKAPE
ADYLDACVVS VLQIHVTQPP GDILVFLTGQ EEIEACCELL QERCRRLGSK IAELLILPIY
ANLPSDMQAK IFTPTPPGAR KVVVATNIAE TSLTIDGIIY VIDPGFCKQK SYNARTGMES
LIVTPCSRAS ANQRAGRAGR VAAGKCFRLY TAWAFKHEME ETTVPEIQRT NLGNVVLLLK
SLGINDLIHF DFMDPPPHET LVLALEQLYA LGALNHLGEL TKLGRRMAEL PVDPMLSKMI
LASEQYKCSE EVLTIAAMLS VNNSIFYRPK DKVVHADNAR MNFVVPGGDH LVLLNVYTQW
VESGYSTQWC YENFIQFRSM RRARDVRDQL EGLMERIEVE VVSCQGENVP IRKAVTAGYF
YHTARLSKGG YKTVKHQQTV YTHPNSSLFE EQPRWLIYHE LVFTTKEFMR QVIEIESAWL
LEVAPHYYKS KELEDSSNKK MPRKQGKAKE ELG
//
