ID A0A3B3CK55_ORYME Unreviewed; 904 AA.
AC A0A3B3CK55;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Huntingtin interacting protein 1 related {ECO:0000313|Ensembl:ENSOMEP00000017725.1};
GN Name=HIP1R {ECO:0000313|Ensembl:ENSOMEP00000017725.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000017725.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000017725.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SLA2 family.
CC {ECO:0000256|ARBA:ARBA00010135}.
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DR AlphaFoldDB; A0A3B3CK55; -.
DR Ensembl; ENSOMET00000026547.1; ENSOMEP00000017725.1; ENSOMEG00000021109.1.
DR GeneTree; ENSGT00940000153594; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR Gene3D; 1.20.5.1700; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 6.10.250.920; -; 1.
DR Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR InterPro; IPR011417; ANTH_dom.
DR InterPro; IPR013809; ENTH.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR032422; HIP1_clath-bd.
DR InterPro; IPR035964; I/LWEQ_dom_sf.
DR InterPro; IPR002558; ILWEQ_dom.
DR InterPro; IPR030224; Sla2_fam.
DR PANTHER; PTHR10407; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR10407:SF10; HUNTINGTIN-INTERACTING PROTEIN 1-RELATED PROTEIN; 1.
DR Pfam; PF07651; ANTH; 2.
DR Pfam; PF16515; HIP1_clath_bdg; 1.
DR Pfam; PF01608; I_LWEQ; 1.
DR SMART; SM00273; ENTH; 1.
DR SMART; SM00307; ILWEQ; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF109885; I/LWEQ domain; 1.
DR PROSITE; PS50945; I_LWEQ; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT DOMAIN 681..904
FT /note="I/LWEQ"
FT /evidence="ECO:0000259|PROSITE:PS50945"
FT COILED 397..424
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 468..520
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 904 AA; 101738 MW; 80776A9C74EDEF2B CRC64;
LQSLSKIVAT NESPPKEKYV RNIILGTHKE TGATTFWSYA VNLPVSSNSM VSWKFCYLLH
KVLRDGHRNV STGPGNLHDR YGHIVALYTK YLHLKMEFHA KVKTSVLKDV CLQSFICKFE
LSFVRVLRQL DANGAKSTTP AGQCRLTPLI PLILDSSFLY HFSVRLLFKL HSRSSLLGHK
SLKFAVWFTA VFVCSLTHFY KRAREMEFFK SVIQIPDLPD EPPNFLRAAA LAEYKKPVVV
MPGEDYQEEE VETHPEFREI PQMPQMPQVR LDMNKTKYYL SSRTDGWRRE MEALKPEIQI
IKDEAQKSVI ELTTQLSHME AELDAQRTHN QVAMIENEHL RMEVEALRFW FLEETRTSER
RAQAAELRFS QLKERHAELV TSHADLMKKN AEAVRMLSSS KQEQDDLLRT KTNLEKELDN
LRWDKQTKVR LLFLDLLCVM HLSRAEVALL RSSLESKETS GTQLNSTLAG LQAEKEVLLR
SVREQEAELN SLRQQAHLQH SSLEQERQRS SMELGSLQAQ LQQQACRETE LAQKLQNEQF
ALLQCAVVEA EGIILDAVAK LDDPIHVRCT SSPDYLVNRA EVTLGSIDKL QQSHLVYLGN
RSDASGLLRA VTQFSHLAAD TIVNGAATSH SAPVDHADSL SDSCRDCANQ CLQFLKDLKF
QPTLPQANAS AIRYSDLRPK GQDVLKEELG TMVDKEMVAT STAIEDAVLR MDEILSQARR
DTTGLKLEVN QSILGSCSDL MKAVHILVTA ATDLQKDIVE GGRGAASTTE FYAKNSRWTE
GLISASKAVG WGATQLLDSA DRVVSEKGTY EELIACSHEI AGSTAQLVAA SKVKADRSNK
KLNTLQQASR HVNDMAAVVV TSTKHGQKQI SDHGLMDFSG MSLIKLKKEE MEAQVRPVKK
NDMK
//
