ID   A0A3B3CK81_ORYME        Unreviewed;       985 AA.
AC   A0A3B3CK81;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Huntingtin interacting protein 1 related {ECO:0000313|Ensembl:ENSOMEP00000018278.1};
GN   Name=HIP1R {ECO:0000313|Ensembl:ENSOMEP00000018278.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000018278.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000018278.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the SLA2 family.
CC       {ECO:0000256|ARBA:ARBA00010135}.
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DR   AlphaFoldDB; A0A3B3CK81; -.
DR   Ensembl; ENSOMET00000027226.1; ENSOMEP00000018278.1; ENSOMEG00000021109.1.
DR   GeneTree; ENSGT00940000153594; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR   GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR   GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR   Gene3D; 1.20.5.1700; -; 1.
DR   Gene3D; 1.25.40.90; -; 1.
DR   Gene3D; 6.10.250.920; -; 1.
DR   Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR   InterPro; IPR011417; ANTH_dom.
DR   InterPro; IPR013809; ENTH.
DR   InterPro; IPR008942; ENTH_VHS.
DR   InterPro; IPR032422; HIP1_clath-bd.
DR   InterPro; IPR035964; I/LWEQ_dom_sf.
DR   InterPro; IPR002558; ILWEQ_dom.
DR   InterPro; IPR030224; Sla2_fam.
DR   PANTHER; PTHR10407; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR   PANTHER; PTHR10407:SF10; HUNTINGTIN-INTERACTING PROTEIN 1-RELATED PROTEIN; 1.
DR   Pfam; PF07651; ANTH; 2.
DR   Pfam; PF16515; HIP1_clath_bdg; 1.
DR   Pfam; PF01608; I_LWEQ; 1.
DR   SMART; SM00273; ENTH; 1.
DR   SMART; SM00307; ILWEQ; 1.
DR   SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR   SUPFAM; SSF109885; I/LWEQ domain; 1.
DR   PROSITE; PS50945; I_LWEQ; 1.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT   DOMAIN          670..911
FT                   /note="I/LWEQ"
FT                   /evidence="ECO:0000259|PROSITE:PS50945"
FT   REGION          905..958
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          353..506
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        924..938
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        939..958
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   985 AA;  110248 MW;  3BB094F70995251E CRC64;
     FLFQLQSLSK IVATNESPPK EKYVRNIILG THKETGATTF WSYAVNLPVS SNSMVSWKFC
     YLLHKVLRDG HRNVSTGPGN LHDRYGHIVA LYTKYLHLKM EFHAKVKTSV LKDVCLQSFI
     CKFELSFVRV LRQLDANGAK STTPAGQCRL TPLIPLILDS SFLYHFSVRL LFKLHSRSSL
     LGHKSLKFAV WFTAVFVCSL THFYKRAREM EFFKSVIQIP DLPDEPPNFL RAAALAEYKK
     PVVVMPGEDY QEEEQYYLLS QMGAPEVPAE PVETETDGWR REMEALKPEI QIIKDEAQKS
     VIELTTQLSH MEAELDAQRT HNQVAMIENE HLRMEVEALR AANVVGVGAQ IGYKEADGRA
     QAAELRFSQL KERHAELVTS HADLMKKNAE AVRMLSSSKQ EQDDLLRTKT NLEKELDNLR
     WDKRELDSTR AELTRANSAL QSKEMSGTQL NSTLAGLQAE KEVLLRSVRE QEAELNSLRQ
     QAHLQHSSLE QERQRSSMEL GSLQAQLQQQ LAQKLQNEQF ALLQCAVVEA EGIILDAVAK
     LDDPIHVRCT SSPDYLVNRA EVTLGSIDKL QQSHLVYLGN RSDASGLLRA VTQFSHLAAD
     TIVNGAATSH SAPVDHADSL SDSCRDCANQ CLQFLKDLKF QPTLPQANAS AIRYSVQRIL
     AMGQDLRPKG QDVLKEELGT MVDKEMVATS TAIEDAVLRM DILSQARRDT TGLKLEVNQS
     ILGSCSDLMK AVHILVTAAT DLQKDIVEGG RGAASTTEFY AKNSRWTEGL ISASKAVGWG
     ATQLLDSADR VVSEKGTYEE LIACSHEIAG STAQLVAASK VKADRSNKKL NTLQQASRHV
     NDMAAVVVTS TKHGQKQISD HGLMDFSGMS LIKLKKEEME AQVRPVLQLE NQLEQERIRL
     GELRKRHYDL GPSGPASNLK EEEDNFPPPP PPTLLDSTPL PPSFSQTQPY LNTQTPQVTQ
     PYSQPQLYYY YTLYLVIIHF FNVTI
//