ID A0A3B3CN00_ORYME Unreviewed; 1114 AA.
AC A0A3B3CN00;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=MutL homolog 3 {ECO:0000313|Ensembl:ENSOMEP00000019253.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000019253.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000019253.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR AlphaFoldDB; A0A3B3CN00; -.
DR STRING; 30732.ENSOMEP00000019253; -.
DR PaxDb; 30732-ENSOMEP00000019253; -.
DR Ensembl; ENSOMET00000028478.1; ENSOMEP00000019253.1; ENSOMEG00000021076.1.
DR GeneTree; ENSGT00800000124176; -.
DR OMA; HIGREGH; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03486; MutL_Trans_MLH3; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF47; DNA MISMATCH REPAIR PROTEIN MLH3; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 211..346
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 866..1049
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 406..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 541..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 640..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 712..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..449
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1114 AA; 124512 MW; 10D24B1B52A03BD5 CRC64;
MIKLLPPEVQ GHLRSGVAIP SLQQCVEELV LNSIDAGATC VGVRMDLEAF KVQVIDNGAG
MNAEDMERVG TRYHTSKCGS LEDLDNIKSH GFRGEALASI VSMATLVEIS SRPRASAKTH
VKLFKDGRGV DVFEAETDRP SAGTTVIICN FFHNMPVRRR RLDPVLEGER IRHRVEAVSL
MHPSVSFTLK NDSTGAMMVQ LPKAKSTYHR FLQIHGLTRA EKLGEISHTY KQFEAVGYLG
KEGHYNNSLQ FLYVNERLLL KTRIHKLLNL LLRRLRQKPD TSDGPPVLKS PKNKQTHELF
GVYILNIKCS YSEYDICFEP AKTLIEFKDW EEVLLCVEEA VKAFLRRENL TSEFSQEDLD
FVSPKVFGPS RADQEVDQTR AAPPDISTMD CSVGMKLASE FVHRRRTDGG ACPEPGLTKN
KTEETEESGQ TGASVDESQT TTQVESEGSG GVKNAKMPNE HEWELSEDVR QSGSSTCSFS
QLVSNDLNCS KCIINIHNTG RPQQSLESNR KISLSEPVIH NILQIPKQSQ TNKVTFPEQR
LEKNSQDKYI APKRKISLNT APDRSTENPH RDLSSNPPTK ISRIFPCQKP SVFKESGSLD
RFRRMYAQSG EMKLPRQHQQ KGPQTSSRVI ISSSLSFCNN DLKEPKTTEA QGDEEKQSSS
LNPPCFSTVK TTNKNKLSFS AKLSQLKEKR KEDAEVSLHA SSSMLEKNIC NKGTEEDSTS
QNPPNTAVYA GSSPRHRTSP HQTGNEEDSA SSVWLHHYNT YVGQTVYVNR MTGLSRYDNP
AEETQVPCTS DVTNMAVSVF SETDAATESS NSLSVMYSKW KNPVFVQPPE VGVDISGGQA
DGLVVKIHSV LFPYRLSKAM IHSMKVIDQV DKKFLACLIN TSEEELTLEG ETEGNLLVLV
DQHAAHERVR LENLITDSYE DIPETFGEKW LCSSSIVPPL EISVTEEELR LLSSCRSQLR
SLGLEVTFSE TQMSSVFVGK VPRCFLEKET NELKRGRPSI IKTIVEEFLQ EQIELLLSTG
RVKGTLPITV LKVLASLACH GAVKFNDVLN RDECHSLVAS LSSCQLPFQC AHGRPSIAPL
VDINHLDEDP KDVQKPNLKK LRRMYEEWKL RGNI
//
