ID A0A3B3CNH2_ORYME Unreviewed; 1706 AA.
AC A0A3B3CNH2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=LDL receptor related protein 5 {ECO:0000313|Ensembl:ENSOMEP00000019397.1};
DE SubName: Full=Low-density lipoprotein receptor-related protein 5 {ECO:0000313|EMBL:KAF6716306.1};
GN ORFNames=FQA47_021504 {ECO:0000313|EMBL:KAF6716306.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000019397.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000019397.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|EMBL:KAF6716306.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bigg-433 {ECO:0000313|EMBL:KAF6716306.1};
RX PubMed=32938378;
RA Liang P., Saqib H.S.A., Ni X., Shen Y.;
RT "Long-read sequencing and de novo genome assembly of marine medaka (Oryzias
RT melastigma).";
RL BMC Genomics 21:0-0(0).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; WKFB01000974; KAF6716306.1; -; Genomic_DNA.
DR STRING; 30732.ENSOMEP00000019397; -.
DR PaxDb; 30732-ENSOMEP00000019397; -.
DR Ensembl; ENSOMET00000035654.1; ENSOMEP00000019397.1; ENSOMEG00000021239.1.
DR GeneTree; ENSGT00940000156574; -.
DR OMA; HTPCEDN; -.
DR Proteomes; UP000261560; Unplaced.
DR Proteomes; UP000646548; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035676; P:anterior lateral line neuromast hair cell development; IEA:Ensembl.
DR GO; GO:0030282; P:bone mineralization; IEA:Ensembl.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0031101; P:fin regeneration; IEA:Ensembl.
DR GO; GO:0001889; P:liver development; IEA:Ensembl.
DR GO; GO:0001755; P:neural crest cell migration; IEA:Ensembl.
DR GO; GO:0032474; P:otolith morphogenesis; IEA:Ensembl.
DR GO; GO:0035677; P:posterior lateral line neuromast hair cell development; IEA:Ensembl.
DR GO; GO:0030500; P:regulation of bone mineralization; IEA:Ensembl.
DR GO; GO:0045124; P:regulation of bone resorption; IEA:Ensembl.
DR GO; GO:0030111; P:regulation of Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR CDD; cd00112; LDLa; 3.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 3.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR46513:SF16; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF14670; FXa_inhibition; 4.
DR Pfam; PF00057; Ldl_recept_a; 3.
DR Pfam; PF00058; Ldl_recept_b; 10.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00192; LDLa; 3.
DR SMART; SM00135; LY; 20.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57424; LDL receptor-like module; 3.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 3.
DR PROSITE; PS51120; LDLRB; 14.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|EMBL:KAF6716306.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KAF6716306.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000646548};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1459..1479
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 189..231
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 232..275
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 276..318
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 367..406
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 454..496
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 497..539
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 540..583
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 584..626
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 673..710
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 756..798
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 799..847
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 848..890
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 931..974
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 981..1018
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 1109..1151
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1152..1196
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1197..1239
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 1289..1327
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1551..1582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1652..1706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1551..1567
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1673..1687
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1692..1706
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1353..1368
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1371..1383
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1378..1396
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1390..1405
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1409..1421
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1416..1434
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1428..1443
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1706 AA; 190094 MW; 8D505CA69EF42CCD CRC64;
MEAPPTSNCP FSPSSSPTVQ SVKSRELKPK TRKSAFYRRS DARAHVHAQR RVSEDARDRT
SEHGAGVPAV TGMGGLLAPR LLLWSCLLSA GSGSPLLLFA NRRDVRLVDG EGVRGESAIV
VSDLEDAAAV DFFFEEGLIF WTDVSEEAIK QTRWNQSSNS LKESLGTDQT VVVPGLDSPD
GLACDWLSKK LYWTDSETNR IEVANLDGSS RKVLFWMDLD QPRAIALNPA QRYMYWTDWG
EEPRIERAGM DGRRREVIIN EDIFWPNGLT VDLEEQKLYW ADAKLSFIHR ANLDGSARET
VVEGTLTHPF ALTLSNETLF WTDWQTHSIH ACNKHRGDKT REILGGIYSP MGIQVLESYR
QPYIRTPCSD NNGGCSHLCL LSPVPPFYSC TCPTGVQLRA DGKTCKPGAE QVLLLARRTD
LRRISLDLPD FTDIVLQVDG IRHAIAIDYD PVEGYVYWTD DEVRAIRRSR LDGSNAVMLV
TTEINHPDGI AVDWVSRNLY WTDTGTDRIE VTRLNGTSRK ILISENLDEP RAIVLDPVNG
YMFWSDWGER PKIERANLDG TDRMVLLNTS LGWPNGLALD YATGKLYWGD AKTDKIEVIS
VDGTGRKTLL EDKLPHIFGF TLLGDYIYWT DWQRRSIERV HKATAVREII IDQLPDLMGL
KATKVTETHG TNGCAVENGG CSHLCFWRRR AVSCACPMGM ELLPDLQTCV VPEAFLLFTN
RDSIRSISLG TNSNDVAIPL TGIKEASALD FDVSERRIYW TDIQAKTISR AYMNGSSVEH
VIEFGLDYPE GMAVDWMGHN IYWADTGTNR IEVARLDGQY RQVLVCKDLD NPRSLDNPRS
LALDPANGFM YWTEWGGLPR IARAYMDGST ITTLVEKVGR ANGLTIDYVD HRLYWTDLDT
YMIESSNMQG LQREIVVDDL PHPFGLTQYK DFIYWTDFNL RTIERADKRG GLNRTVILKG
QLELMMDILV FHSSRQDGTN ECSQNNGDCA HLCLATPAGA QCRCASHYTL NSDGRNCSSP
SSFLLFTQKN SISRMVLGEQ SPDIILPIHV VKARAVRYDP LDRLIYWLDG RQNIRRARDD
GAMSSVMVTG TAQPVENQLH DLSLDPYSRH VYWTCENTNT INVQRMDGHI VGVVVKDDTD
KPRAIVVNAE RGYMYFTTVQ ERSAKIEGAS LDGTERESLF TTGLIRPVAL ALDNKLGKLF
WVDADLKRIE SSDLTGANRV VLQDSNILQP MGLTVLGEHL YWIDRQQQMI ERVDKLTGDR
RTRVQGRISF LTSIHAVEKM DPREFELHPC ARNNGGCSHI CIAKGDGTPR CSCPIHLVLA
SDLLRCGEPP TCSPEQFTCS TGDIDCIPLA WRCDGFPECE DGSDEDNCPV CSVSHFQCDE
GSCIDAHKRC DGEADCADKS DEHDCEVICS PGEFRCGDNQ CITKKQRCDG YSDCPDGLDE
LACDHAPPPS TFNHDPKPII PVIAIMLLVF VIGGVYFACQ RVEWRCYKGP NGTFPRDYIS
GTPHVPLNFI APSGSQHGTF QGISCGKSIM SSVSLMGSSS SGAPLYDRNH VTGASSSSSS
STKGAYYPQI LNPPPSPATD RSLYNTEIYS SNSPSTTRSY RPYHAIRGAA PPTTPCSTDV
CDSDYTPHHL SAGLPPSAGR WKASAHNGKH NKYYMDLNSD SDPYPPPPTP RSQYMSAEES
CPPSPSTERS YFHLCPPPPS PCTDSS
//
