ID   A0A3B3CPE9_ORYME        Unreviewed;      1170 AA.
AC   A0A3B3CPE9;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Sortilin related VPS10 domain containing receptor 1 {ECO:0000313|Ensembl:ENSOMEP00000019225.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000019225.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000019225.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC       subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR   AlphaFoldDB; A0A3B3CPE9; -.
DR   STRING; 30732.ENSOMEP00000019225; -.
DR   PaxDb; 30732-ENSOMEP00000019225; -.
DR   Ensembl; ENSOMET00000028416.1; ENSOMEP00000019225.1; ENSOMEG00000021072.1.
DR   GeneTree; ENSGT01030000234563; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   CDD; cd00146; PKD; 1.
DR   Gene3D; 2.10.70.80; -; 1.
DR   Gene3D; 3.30.60.270; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR000601; PKD_dom.
DR   InterPro; IPR035986; PKD_dom_sf.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR   PANTHER; PTHR12106:SF8; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1; 1.
DR   Pfam; PF00801; PKD; 1.
DR   Pfam; PF15902; Sortilin-Vps10; 1.
DR   Pfam; PF15901; Sortilin_C; 1.
DR   SMART; SM00602; VPS10; 1.
DR   SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR   SUPFAM; SSF49299; PKD domain; 2.
DR   PROSITE; PS50093; PKD; 1.
PE   3: Inferred from homology;
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          848..915
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
FT   REGION          55..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          160..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        63..84
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        178..193
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        214..239
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1170 AA;  130148 MW;  057D1E1CD689C99E CRC64;
     MKVENNNCGK RQSQHCPLAR LNARLLPRAR RASFHQTLQV GARGLSRTLV CAAPAAGSGR
     QTEESRNGDR ASQTTEHADM DRHAGLSPKW PRALWCLLLL TPCLLHAATA EITCRSCHLG
     NKWRARELLI KLNTEESGTG VQGELLGTHG LPCQGGLAEC APNPEPRLKR STGSRRADDF
     AQSKVSATFG TRARRSSGGD LAGDPAAADH QDAQTGRRVL RAELRWSGEE RRSAGGRHEE
     PKVNSSTFAL TGDSSHNQAM VHWSGQNSSI MLLTDPEVES SLLISSDEGA TYQKYRLNFY
     ILSLLFHPEQ EDWILAYSHD QKLYSSVEFG RRWQLVHERV APNRFYWSKM GLDKEPGLIH
     LETSISEGQA LYVTCKLQNC TDSNKGKPFP GYIDPNSLVV QDEYVFVQVS TPGRPVYYVS
     AKRDVFTPMK LPKYTLPKEL HVISTDDNRV VAAVQEWNQN ETYNLYVSDT SGVYYTLALE
     NVVSSMGLEG NVMVDLYEVA GIKGMFLANK KMDNQVKTHI TYNRGRDWRL LQAPSRDLRG
     NSIHCVLPYC SLHLHLHVST NPYTSGNIAS RDSTPGIIVA SGSIGSELTT TNVSVFITSD
     AGNTWRQIFD EEYAVLYLDQ GGALVAIRHT PLPIRHLWLS FDEGRQWNKY SFTNTPLFVD
     GVLGEPGEET LIMTIFGHFS HRSEWQLVKI DFRSIFNRRC TEADYQTWHL HNQGEPCLMG
     VKRIYRKLKP TSRCVMGKMY SVAMTSSPCD CMEADFECDY GYERRSDGKC SPAFWFHPSS
     MSRSCTTGMT FLNSTGYRKV ISNNCTAGVS AEFTARRLHC PLQAPRGLHL VTSEGALTAT
     LGSNITFLVF LEEGDGARTS ITIDFGDGHA LTYSNVSTIE DGIKHIYKAV GIYRVTATAE
     NSLGSETATL FLHVTCQLEY IHLSAPFVVV RNKEVNLTAV LWPSQVGTVT YIWWIGNNTE
     PVITLEGSVA CTFSREGVNT VTVQVSAGNA ILQDRKTIAV HEFFRSHLLA FSSNLDEHNP
     DVAEWRLDVS RVIRNSLIQA TGMREDQLLV TVLPGLPTTA EFFLLPDKQV TEGKPEKSSA
     HLDQLSEVVL SALNQNLVQF MLRPGVQVTV HAAHLSAAPL VDTSENHSGS AMLMLLSVVV
     LGLAIFVIYK FKRSQASTSM RRCRTKKNKK
//