ID A0A3B3CRP0_ORYME Unreviewed; 1189 AA.
AC A0A3B3CRP0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRO {ECO:0000313|Ensembl:ENSOMEP00000019975.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000019975.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000019975.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
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DR AlphaFoldDB; A0A3B3CRP0; -.
DR Ensembl; ENSOMET00000029332.1; ENSOMEP00000019975.1; ENSOMEG00000021976.1.
DR GeneTree; ENSGT00940000154814; -.
DR OMA; TISFITX; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR042996; PTPRO.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR47028; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE O; 1.
DR PANTHER; PTHR47028:SF1; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE O; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1189
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017229784"
FT TRANSMEM 821..845
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 326..422
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 432..528
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 529..631
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 675..809
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 726..815
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 911..1168
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1085..1159
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 228..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1189 AA; 133082 MW; 688E14D6769A8D08 CRC64;
MLPASLLVHA LLLCFSQSLT AFQVSVSDDG LIVAALEPSD LQDNVTAYAA QVSGEPRLVL
VPFLNTKEAL LFNASFHGLC YTVGLLLKLG QNWSRPVKSV PVLTKPLPVR SAHISDYKEA
PETGVVFDID PPSRTVFSRV NISYTEGAER RSMLYKDFYR GKTVFKHWLP GVCYRNITFQ
LISEATVNQT ALVTHSDVTH TPLHHRTVPY PPLNVSHKIL HLSPRRVLEG PRPSRQARDV
PLMEEEEEPT PPYEEEGATA TPLAFNTTDA SLGDGTVNGS RAEEAEPQST WLNQTEPPHV
EEDEEFVNAV VPDYEDSNEP GSGMVVPAEP AVLLTRPPPI LLELRWLPPR PPTSYNGFVV
YVYRDGNSTE TAIVDENTHE FFTELSEPGT YRARVSTLSS SGDCEARESS ADAGVTFYLS
PDGELLEELR ERPRGVSVRL LDSSTAAVSW AASSEQHNGS LVSVVSTTCL KPSLSQRMEN
TYCSEENSTS DVISSLTPGA QYRVVVFHTN GPLISPPSEP VIIDIEPTGV RELAVYPLSP
TAVILSWQRP YHVAFRKYVL QTFFFNPVTL ASEWTTYYEI AATASVIASV RVTDLLPAWY
YNFRVSMVTW GEPPLSCCDS STVSFVTAPE APHISSVDYA HGVLSVRWTY GELFIDLSHS
RMLHWQVVAV GRRGPERSYS VDVTRGVMRA SLPLPPGDIY NLTVTACTER SRNTSTPNII
KLEPAPPRSL YAVNATHSSA TLLWSEEGVV DFYQVLCRPC TANKELKAQE PLTSTSHVLT
VSGLTPSSTY NCSVTSVSYS TPSRPAHVTV TTADREMNPS VAAISALAVL SVLLVSLLLL
FLLVLRKKHL QMSRECGAET FVNFPSFERE GKLPYNWSKT ALKKRKLTSP VQLDDFEAYF
KDMGKDSAYK FSLQFEELKS VGLDLSHDAA DLPVNRPKNR YTNILPYDFS RVKLVSMHND
EGADYINANY IPGYKHAKEY IATQGPLPET RNDFWRMVLQ QKAPIIVMLT QCNERRRVKC
DHYWPFTDEP VMYGEVGVEM LSQSESQEWI TRKFRLEYAD ETQDVLHLNY TSWPDHGVPT
VNAIESILQF VHIVRQQANR TKDPIIVHCS AGVGRTGTFI ALDRLMQHMR EHEFVDILGM
VSEMRSHRLS MVQTEEQYVF IHQCVLLMWQ KKKQQSITSD VIYENASKT
//
