ID A0A3B3CS50_ORYME Unreviewed; 453 AA.
AC A0A3B3CS50;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=StAR related lipid transfer domain containing 3 {ECO:0000313|Ensembl:ENSOMEP00000020707.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000020707.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000020707.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747,
CC ChEBI:CHEBI:16113; Evidence={ECO:0000256|ARBA:ARBA00034049};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the STARD3 family.
CC {ECO:0000256|ARBA:ARBA00010909}.
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DR AlphaFoldDB; A0A3B3CS50; -.
DR Ensembl; ENSOMET00000030227.1; ENSOMEP00000020707.1; ENSOMEG00000022604.1.
DR GeneTree; ENSGT00940000159051; -.
DR OMA; AWVETWF; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005770; C:late endosome; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015485; F:cholesterol binding; IEA:InterPro.
DR GO; GO:0120020; F:cholesterol transfer activity; IEA:InterPro.
DR CDD; cd08906; START_STARD3-like; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR019498; MENTAL.
DR InterPro; IPR029867; STARD3_MLN64_C.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR46121:SF2; STAR-RELATED LIPID TRANSFER PROTEIN 3; 1.
DR PANTHER; PTHR46121; STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE; 1.
DR Pfam; PF10457; MENTAL; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR PROSITE; PS51439; MENTAL; 1.
DR PROSITE; PS50848; START; 1.
PE 3: Inferred from homology;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 50..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..219
FT /note="MENTAL"
FT /evidence="ECO:0000259|PROSITE:PS51439"
FT DOMAIN 245..445
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
SQ SEQUENCE 453 AA; 51278 MW; D4A4A105FDE6A227 CRC64;
MQGGEYGELG GSLPAIASLN ASYSTSLSIP SPYMLLPPAK LKAISDVRRT FCLFVTFDFL
FVSLLWIIEL NIHTSDSIWD CLKKEVVEYS FQSSFFDIAL LALFRFLCLQ VGYAAFRLRH
WWVIAVTTLV TTVFLVVKVI ISNQLFSHNA FDYVLPIASF VVAWLETWFL DFKVLTQEAE
DERAYLAAVN AACERAPMIY PRAVSDGQFY SPPESIAGSE EELDEEGLGR KAVTAQEKEY
VRQGKEAMSV VEQILNQEEN WKFEKNNEMG DSVYTLEIPY HGKTFILKAL MQCPAELVYQ
EVILQPEKMV QWNRTVSVCQ ILQRVDDNTL VSYDVSAGAA GGVVSPRDFV NVRRVERKRD
CYLSAGMATN HDLKPPVGRY VRGENGPGGF VVLKSSSNLS VCTFIWVLNT DLKGRLPRYL
INQSLAATMF EFMSHLRQRM AEMRPSLRSQ HPL
//
