ID A0A3B3CUC5_ORYME Unreviewed; 403 AA.
AC A0A3B3CUC5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Class E basic helix-loop-helix protein 40 {ECO:0000256|ARBA:ARBA00040229};
DE AltName: Full=Class B basic helix-loop-helix protein 2 {ECO:0000256|ARBA:ARBA00042387};
GN Name=BHLHE40 {ECO:0000313|Ensembl:ENSOMEP00000021442.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000021442.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000021442.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3B3CUC5; -.
DR Ensembl; ENSOMET00000031098.1; ENSOMEP00000021442.1; ENSOMEG00000023321.1.
DR GeneTree; ENSGT00940000158384; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd19749; bHLH-O_DEC1; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR PANTHER; PTHR10985:SF3; CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 40; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 23..78
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 112..145
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
FT REGION 152..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..237
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..279
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 403 AA; 44770 MW; 4FA34A4A4018B1BB CRC64;
MDFPMYVYKP RRGMKRGEES KDTYKLPHRL IEKKRRDRIN ECIAQLKDLL PEHLKLTTLG
HLEKAVVLEL TLKHVKTLTS LLEQQQQKIL ALQSGMQIEQ PPVNQEKSEE MFRSGFHMCA
KEILHYLAAH ESSGDFTPSH VVNHLHKVAA EVLQGPARPR TPVSPGPSEV PAYHQHDLHK
EKPDNLPPKP SEGYGKNCVP VIQRAYAPPS GEQSGSDTDT DSGYGGELEK PESRVQHQEY
YGPENPQKRS QADRQNSSIK QEDDEPRHKR PRVESSEDEL LSGGESSTSS SSSGYSSYMS
VSPNHPPPPP HPLCMPFYLI PPSAAAYLPM LEKCWYPGAV PMLYPGMGGS SPTMPSDRPS
PPQLVLSPRG GSPAPTLSQT PMDSPALLQA LKQVPPLNLE TKE
//
