ID A0A3B3CV63_ORYME Unreviewed; 1004 AA.
AC A0A3B3CV63;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Phosphoinositide phospholipase C {ECO:0000256|RuleBase:RU361133};
DE EC=3.1.4.11 {ECO:0000256|RuleBase:RU361133};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000021235.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000021235.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-
CC diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456,
CC ChEBI:CHEBI:203600; EC=3.1.4.11;
CC Evidence={ECO:0000256|RuleBase:RU361133};
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DR AlphaFoldDB; A0A3B3CV63; -.
DR Ensembl; ENSOMET00000036499.1; ENSOMEP00000021235.1; ENSOMEG00000023122.1.
DR GeneTree; ENSGT00940000164828; -.
DR OMA; MHGIPAD; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:UniProtKB-EC.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd00275; C2_PLC_like; 1.
DR CDD; cd16206; EFh_PRIP; 1.
DR CDD; cd13364; PH_PLC_eta; 1.
DR CDD; cd08597; PI-PLCc_PRIP_metazoa; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001192; PI-PLC_fam.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR015359; PLC_EF-hand-like.
DR InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR InterPro; IPR001711; PLipase_C_Pinositol-sp_Y.
DR PANTHER; PTHR10336:SF85; PHOSPHOINOSITIDE PHOSPHOLIPASE C; 1.
DR PANTHER; PTHR10336; PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF09279; EF-hand_like; 1.
DR Pfam; PF16457; PH_12; 1.
DR Pfam; PF00388; PI-PLC-X; 1.
DR Pfam; PF00387; PI-PLC-Y; 1.
DR PRINTS; PR00390; PHPHLIPASEC.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00148; PLCXc; 1.
DR SMART; SM00149; PLCYc; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
DR PROSITE; PS50008; PIPLC_Y_DOMAIN; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|RuleBase:RU361133};
KW Lipid degradation {ECO:0000256|RuleBase:RU361133};
KW Lipid metabolism {ECO:0000256|RuleBase:RU361133};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT DOMAIN 15..125
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 492..608
FT /note="PI-PLC Y-box"
FT /evidence="ECO:0000259|PROSITE:PS50008"
FT DOMAIN 608..737
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 971..1004
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 982..1004
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1004 AA; 114069 MW; F67E75FFA38F8064 CRC64;
MPSDRKINST AACMAFMMKG CEMKKVRSNS RMYNRYFLLD PDMHWLRWEP SKKDSEKAKL
EIKSIKEVRL GKKTPVLRSN GLSDQFPDEC AFSIIYGDNY ESLDLVASTP DVVSTWVMGL
RYLVSYGRHT VDMVEPCQQS LRTSWIGSVF ELADVEKDGH IDLFRATQII KGLNPGMKES
RIELKFKELQ KAKDQHGETI NMDSFVEAYC ELCTRPEIFF LLVQFSSNKE YLDSKDLMLF
VDVEQGVEGV TEEMCKDIVQ KFEPSTEGRE RGYLSIDGFT NYLLSSECHI FDPQHKRVCQ
DMTQPLSHYY INSSHNASLL DDHFWGSSDI SSYIRALRMG CRSVEIVVWD GHDSEPVVYI
GSSVASQLAF SKVLDIINQY AFESSEYPLI LCLVTHCCIL QQRVMAQHLK KILGDKLYTE
SPNKEENYLP SPEKLKGKIL LKSKKLPPSC TDAEGDVTDE EEGLEMSRRV GADDKDHLNG
LGCKKIRLCR ELSDLVSLCK SVQFRDFETS KRDQKYWEIC SFNEVDANRF ANEFPEEFVC
YNKRLLSRVY PTPMRIDASN MNPQDFWKCG CQIVAMNYQT PGLMMDLNLG WFRQNGNCGY
VLRPAIMREE VSYFSANARD SLPGVSAQLL HIKIISGQNL PKPRGSAAKG DVVEPYIYVE
IHGIPADCAE QRTKTVSQNG DNPIFDESFE FQINLPELAV LRFVVLDDDY IGDEFIGQYT
IPFECLQPGY RHVPLQSLTG EFLPNTTLFV HVAITNRRGG GKAHKRGLSV RKGRKAREYT
TTKTTGIKAV DELFRASTQP LREATDLREN VQNAMVSFKE LCGLTPAANM KQCILTVSTW
LMNSERSLRV TVDLSETYPT MEAQGPVPEL LRKVLNAYDM MIQTSKTLIE SADVVYSKLT
QAQRAGLDFH EDLHRIGAKE GLKGRKLQKA MESYAWNITV LKGQADLLKH AKIEALDTLR
QIHYAAQSCG LNKNAPKGTS EKKIKVKKKT NKQKKNKLLS GVHQ
//
