ID   A0A3B3CWT9_ORYME        Unreviewed;       967 AA.
AC   A0A3B3CWT9;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE            EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000022278.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000022278.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC       HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
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DR   STRING; 30732.ENSOMEP00000021300; -.
DR   PaxDb; 30732-ENSOMEP00000021300; -.
DR   Ensembl; ENSOMET00000015141.1; ENSOMEP00000022278.1; ENSOMEG00000001760.1.
DR   Ensembl; ENSOMET00000030933.1; ENSOMEP00000021300.1; ENSOMEG00000023162.1.
DR   GeneTree; ENSGT00740000115773; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   CDD; cd09076; L1-EN; 1.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR46238; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR46238:SF8; RIBONUCLEASE H; 1.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   3: Inferred from homology;
FT   DOMAIN          559..818
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
SQ   SEQUENCE   967 AA;  112059 MW;  040BEE3F9D501BE8 CRC64;
     MRIRPTKSIP DRSRPGLTTT AIGAVHRQGA GGNWTTVGGR RRGGRRVRRE REKRKVTSVG
     LRVGTLNVGT MTGKGRELVD MMQRRKVDIL CVQETRWKGS KARSLGAGFK LFYHGGDGKR
     NGVGVILKEE FVRSVVEVKR VSDRVMSLKI EMEGVMFNVV SGYAPQVGCE LEEKEKFWLD
     LDEVMMSIPG NERVVIGADF NGHVGAGNRG DEEVMGRFGI QERNVEGQMV VDLAKKMEMA
     IVNTFFEKRQ EHRVTYKSGG RSTQIDYILC RRCNLKEISD CKVVVGESVS RQHRMVVCRM
     TLVVKKMKKE RAKAEKRTNW WKLKKEDCCM TFKKQLKQAL GGQEVLPDDW ITTANVIRET
     GRSVLGVSSG KRVDKETWWW NEEVQECIRS KRLAKKKWDT ERTEESRQEY REMQRKVKVE
     VSKAKQRAYD DLYARLGSKE GETDLYRLAR QRDRDGKDMQ QVRVIKDRNG NVVTGVSGVM
     ERWKEYFEEL MNEENEREQR VEEVTVVEQE VRKISKGEVR GALKRMKSGK ALGPDDIPVE
     VWKCLGEMAV EFLTGLFNRI LGGEKMPEEW RRSVMVPIFK NKGDVQSCGN YRGIKLMSHT
     MKVWERVVEA RLRAEVNICE QQYGFMPRKS TTDATFALRM LIEKYREGQR ELHCVFVDLE
     KAYDRVPREE LWYCMRKSGV TEKYVRAVQD MYEGCKTVVR CAVGVTEEFK VEVGLHQGSA
     LSPFLFAMVM DRLTDEVRQE SPWTMMFADD IVICSESREQ VEVELERWRF ALERRGMKVS
     RSKTEYMCVN ERNQSGRVRL QGEEIKKVEE FKYLGSTVQS NGECGKEVKR RVQAGWNGWR
     KVSGVMCDRR VSAQMKGKVY KTVVRPAMLF GLETVGLKKR QEAELEVAEM KMLRFSLGVT
     RMDRIRNEYI RGTAHVRGFG DKVREARLRW FGHVQRRDSE YIGRRMLSLE LQERGLEEDQ
     RGGLWMQ
//