ID   A0A3B3CWZ2_ORYME        Unreviewed;       714 AA.
AC   A0A3B3CWZ2;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=X-ray repair cross-complementing protein 5 {ECO:0000256|PIRNR:PIRNR016570};
DE            EC=3.6.4.- {ECO:0000256|PIRNR:PIRNR016570};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000022333.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000022333.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Single-stranded DNA-dependent ATP-dependent helicase.
CC       {ECO:0000256|PIRNR:PIRNR016570}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PIRNR:PIRNR016570}.
CC   -!- SIMILARITY: Belongs to the ku80 family. {ECO:0000256|ARBA:ARBA00007726,
CC       ECO:0000256|PIRNR:PIRNR016570}.
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DR   Ensembl; ENSOMET00000015054.1; ENSOMEP00000022333.1; ENSOMEG00000001816.1.
DR   Ensembl; ENSOMET00000015064.1; ENSOMEP00000000920.1; ENSOMEG00000001816.1.
DR   GeneTree; ENSGT00940000153239; -.
DR   OMA; WAMQYVW; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0043564; C:Ku70:Ku80 complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR   GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR   CDD; cd00873; KU80; 1.
DR   Gene3D; 1.10.1600.10; -; 1.
DR   Gene3D; 2.40.290.10; -; 1.
DR   Gene3D; 1.25.40.240; Ku, C-terminal domain; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR   InterPro; IPR024193; Ku80.
DR   InterPro; IPR005160; Ku_C.
DR   InterPro; IPR036494; Ku_C_sf.
DR   InterPro; IPR005161; Ku_N.
DR   InterPro; IPR014893; Ku_PK_bind.
DR   InterPro; IPR016194; SPOC-like_C_dom_sf.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR12604; KU AUTOANTIGEN DNA HELICASE; 1.
DR   PANTHER; PTHR12604:SF4; X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5; 1.
DR   Pfam; PF02735; Ku; 1.
DR   Pfam; PF03730; Ku_C; 1.
DR   Pfam; PF03731; Ku_N; 1.
DR   Pfam; PF08785; Ku_PK_bind; 1.
DR   PIRSF; PIRSF016570; Ku80; 1.
DR   SMART; SM00559; Ku78; 1.
DR   SUPFAM; SSF101420; C-terminal domain of Ku80; 1.
DR   SUPFAM; SSF100939; SPOC domain-like; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR016570};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR016570};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172,
KW   ECO:0000256|PIRNR:PIRNR016570};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|PIRNR:PIRNR016570};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR016570};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PIRNR:PIRNR016570};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR016570};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|PIRNR:PIRNR016570};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR016570}.
FT   DOMAIN          285..424
FT                   /note="Ku"
FT                   /evidence="ECO:0000259|SMART:SM00559"
FT   REGION          158..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   714 AA;  81120 MW;  317BF5356D5F0A9D CRC64;
     MDVGFSMSNS SPGEESPFDL SKKVIQKFVQ RQVFAETKDE VALVLFGTDA TKNPLEEDEQ
     YQNIVVHRHL MVPDFELLEE IEHQIHPEGQ QADWLDALVV CMDLLQKETQ GKKCDRLNIV
     LLTDLCTPAS PDKLEVIVEN LKQAEITLQF FLPFPVEDDE EGEEDGEHGD PGHPGAGKGL
     SREQQSGLEM VKHIMLSLDE EDGLNEVYTF RNAIEQLRMF KRIERRPMAW PCQLTIGSSL
     SIRIVGYKAV TEERLKKMWI TVDAQTNNKE DVKRETVYCL DDDNETEVQK EDIIQGFRYG
     SDIVPFSKVD QEQMKYKHDG KSFAVLGFTK QHLVFRHQFM GSQVVKIFPP KDDEHAGVAL
     SALIRGLDEL KMVAIVRYAY DRRSNPQVGA AFPCIKQNYE CLIYVQLPFM EDLRPFAFPS
     LENNKKICPS ETQLSAVDSL IDSMMLVEKD ESGDLIDLLK PHHIPNPAFQ RHFQCLHHRA
     VNPGTPLPPL EPWLQAVLDR PEVIKERCQA SLEEIKRKFP LTEVEKKKKL KTSAQIFGKD
     SNEANADKGK EDEAEEEYNL ADIAEGSVTS VGSVDPARDF HLLLKQKSLP FGEVCQQLTH
     RIEQLLSNKN TQYYMKSITC IQAFREQSVK MANADLYNSY LQSLKRSIPS RGLEVFWDLL
     VQDGVTLISN EEVSGSLISK NEANEFLKAE EIKEEAAAPP AEDTGDVDDL LDMM
//