ID A0A3B3CY17_ORYME Unreviewed; 894 AA.
AC A0A3B3CY17;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000022210.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000022210.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|RuleBase:RU367118}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|RuleBase:RU367118}.
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DR AlphaFoldDB; A0A3B3CY17; -.
DR Ensembl; ENSOMET00000015322.1; ENSOMEP00000022210.1; ENSOMEG00000001682.1.
DR GeneTree; ENSGT00940000157342; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022824; F:transmitter-gated monoatomic ion channel activity; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:UniProt.
DR CDD; cd13729; PBP2_iGluR_AMPA_GluR1; 1.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966:SF513; AMPA RECEPTOR SUBUNIT GLUR1B; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU367118};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT CHAIN 25..894
FT /note="Glutamate receptor"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT /id="PRO_5027147660"
FT DOMAIN 399..773
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 409..474
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 894 AA; 99312 MW; ACD2067C3B077176 CRC64;
MRGFPARAAP PLPPLLLLLG LCSGTSFPGN VNIGGLFPTG SHEYEVFRFA LSQHQDVSKL
VPQVDMVDTG SSFAMTYAFC SQFSKGVYAI MGLYDRRTVN MLMSFCGSLH VCFVTPSFPV
QTNNQFVLQL RPQLQEPLMA LLEHFFWTRF VYMYSSDSGL TVLQKILDTA AEQSWQVTSV
NLDALTEAAF IKLLADLDYK KDFQIIINCE LERLNYILNL VKNLKNYHFI LANLGFLDLN
VTEFQKLAPN VTGFQLVNRT DPAIFAVALD LNLDWILDYT GALTYDGINV MATAFQNLRQ
QRIDISRRGN AGECLANPPA PWGQGIDIQR ALQQVHLEGL TGHVQFDERG HRTNYTLTVM
ELSHLGPRKI GQWTEKTGYV HTAVYRPLQE EFFGLLNKTY VVTTILEAPY MMLKKNHEQF
VGNDKYEGYC AELASEIAKH VGFAYRLELV SDGKYGARDA ESKMWNGMVG ELVYGKADMA
VAPLTITLVR EQVIDFTKPF MSLGISIMIK KPTKSKPGVF SFLDPLAYEI WMCIVFAYIG
VSVVLFLVSR FSPYEWQGED SDDEDEDTPE YTNDFGIFNS LWFSLGAFMQ QGCDISPRSL
SGRIVGGVWW FFTLIIISSY TANLAAFLTV ERMVSPIESA EDLAKQTEIA YGTLDGGSTK
EFFRRSKIAV FEKMWSYMRS AEPSVFVKST TDGVIRVRKS KGKYAYLLES SMNEYIEQRK
PCDTMKVGGN LDSKGYGVAT PKGSPLRNPV NLAVLKLNEQ GLLDKLKNRW WYDKGECGTG
GGDSKDKTSA LSLSNVAGVF YILIGGLGLA MMVALVEFCY KSRIESRRMK VSLTDASNHL
ATGGGDPGIP ACGLGGGLTG ENGRVVTHEF PNFGVQGLPC MSKAAGLGMS STGM
//
