ID A0A3B3CYD8_ORYME Unreviewed; 725 AA.
AC A0A3B3CYD8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=X-ray repair cross-complementing protein 5 {ECO:0000256|PIRNR:PIRNR016570};
DE EC=3.6.4.- {ECO:0000256|PIRNR:PIRNR016570};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000022315.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000022315.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Single-stranded DNA-dependent ATP-dependent helicase.
CC {ECO:0000256|PIRNR:PIRNR016570}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR016570}.
CC -!- SIMILARITY: Belongs to the ku80 family. {ECO:0000256|ARBA:ARBA00007726,
CC ECO:0000256|PIRNR:PIRNR016570}.
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DR AlphaFoldDB; A0A3B3CYD8; -.
DR STRING; 30732.ENSOMEP00000022315; -.
DR PaxDb; 30732-ENSOMEP00000022315; -.
DR Ensembl; ENSOMET00000015078.1; ENSOMEP00000022315.1; ENSOMEG00000001816.1.
DR GeneTree; ENSGT00940000153239; -.
DR OMA; WAMQYVW; -.
DR OrthoDB; 5884at2759; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0043564; C:Ku70:Ku80 complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0010212; P:response to ionizing radiation; IEA:Ensembl.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd00873; KU80; 1.
DR Gene3D; 1.10.1600.10; -; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 1.25.40.240; Ku, C-terminal domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR024193; Ku80.
DR InterPro; IPR005160; Ku_C.
DR InterPro; IPR036494; Ku_C_sf.
DR InterPro; IPR005161; Ku_N.
DR InterPro; IPR014893; Ku_PK_bind.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR12604; KU AUTOANTIGEN DNA HELICASE; 1.
DR PANTHER; PTHR12604:SF4; X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5; 1.
DR Pfam; PF02735; Ku; 1.
DR Pfam; PF03730; Ku_C; 1.
DR Pfam; PF03731; Ku_N; 1.
DR Pfam; PF08785; Ku_PK_bind; 1.
DR PIRSF; PIRSF016570; Ku80; 1.
DR SMART; SM00559; Ku78; 1.
DR SUPFAM; SSF101420; C-terminal domain of Ku80; 1.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR016570};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR016570};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172,
KW ECO:0000256|PIRNR:PIRNR016570};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|PIRNR:PIRNR016570};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR016570};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PIRNR:PIRNR016570};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR016570};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR016570};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR016570}.
FT DOMAIN 296..435
FT /note="Ku"
FT /evidence="ECO:0000259|SMART:SM00559"
FT REGION 169..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 725 AA; 82165 MW; C036C3E681BEA13A CRC64;
MAGAKSALVL CMDVGFSMSN SSPGEESPFD LSKKVIQKFV QRQVFAETKD EVALVLFGTD
ATKNPLEEDE QYQNIVVHRH LMVPDFELLE EIEHQIHPEG QQADWLDALV VCMDLLQKET
QGKKCDRLNI VLLTDLCTPA SPDKLEVIVE NLKQAEITLQ FFLPFPVEDD EEGEEDGEHG
DPGHPGAGKG LSREQQSGLE MVKHIMLSLD EEDGLNEVYT FRNAIEQLRM FKRIERRPMA
WPCQLTIGSS LSIRIVGYKA VTEERLKKMW ITVDAQTNNK EDVKRETVYC LDDDNETEVQ
KEDIIQGFRY GSDIVPFSKV DQEQMKYKHD GKSFAVLGFT KQHLVFRHQF MGSQVVKIFP
PKDDEHAGVA LSALIRGLDE LKMVAIVRYA YDRRSNPQVG AAFPCIKQNY ECLIYVQLPF
MEDLRPFAFP SLENNKKICP SETQLSAVDS LIDSMMLVEK DESGDLIDLL KPHHIPNPAF
QRHFQCLHHR AVNPGTPLPP LEPWLQAVLD RPEVIKERCQ ASLEEIKRKF PLTEVEKKKK
LKTSAQIFGK DSNEANADKG KEDEAEEEYN LADIAEGSVT SVGSVDPARD FHLLLKQKSL
PFGEVCQQLT HRIEQLLSNK NTQYYMKSIT CIQAFREQSV KMANADLYNS YLQSLKRSIP
SRGLEVFWDL LVQDGVTLIS NEEVSGSLIS KNEANEFLKA EEIKEEAAAP PAEDTGDVDD
LLDMM
//
