ID A0A3B3D1V6_ORYME Unreviewed; 1246 AA.
AC A0A3B3D1V6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000023525.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000023525.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3B3D1V6; -.
DR STRING; 30732.ENSOMEP00000023525; -.
DR PaxDb; 30732-ENSOMEP00000023525; -.
DR Ensembl; ENSOMET00000012003.1; ENSOMEP00000023525.1; ENSOMEG00000003684.1.
DR GeneTree; ENSGT00940000164854; -.
DR OMA; HECVEHP; -.
DR OrthoDB; 5475408at2759; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005112; F:Notch binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 13.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 15.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR026219; Jagged/Serrate.
DR InterPro; IPR011651; Notch_ligand_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR PANTHER; PTHR24044:SF421; PROTEIN JAGGED-2; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 2.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 8.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF12661; hEGF; 4.
DR Pfam; PF07657; MNNL; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR02059; JAGGEDFAMILY.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 16.
DR SMART; SM00179; EGF_CA; 14.
DR SMART; SM00214; VWC; 1.
DR SMART; SM00215; VWC_out; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 6.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 8.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 15.
DR PROSITE; PS01186; EGF_2; 10.
DR PROSITE; PS50026; EGF_3; 14.
DR PROSITE; PS01187; EGF_CA; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1246
FT /note="Delta-like protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017375375"
FT TRANSMEM 1080..1104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 189..233
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 300..338
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 340..376
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 378..414
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 416..452
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 454..489
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 491..527
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 529..565
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 593..629
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 631..667
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 669..705
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 707..743
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 746..782
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 784..820
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 822..858
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1152..1174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 191..200
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 204..216
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 224..233
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 328..337
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 366..375
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 404..413
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 442..451
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 458..468
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 479..488
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 517..526
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 555..564
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 619..628
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 657..666
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 695..704
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 733..742
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 772..781
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 810..819
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 848..857
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1246 AA; 137327 MW; 04BF7D12E002051E CRC64;
MWNHPVKVQR FSVACFLFTV WAEVSQCTGY FELQLLSLDN PRGQLLSGDC CDSTRIAARG
VCGEDECDTY FRVCLKEYQT EVTTTGPCTY GSEITEVFGG NIFHFKSDQK SGLNRNNDAG
KILIPFQFAW PRAFTVIVEA WDWDNSTHSS DEELLIERSI HKGMINPGEE KQTVEHKSLV
TSMQYTIRVR CHEHYYGSKC NQVCRPRDDY FGHYVCDQMG NRKCMEGWTG PDCKTAICKP
GCHSTHGTCS IPGECKCKYG WDGLLCDQCL PYPGCVHGTC NEPWKCTCEK NWGGLLCDKD
LNYCGTNWPC KNGGTCMNTE PDEYNCACPD GYSGKNCEIV EHACVSDPCA NGGTCHEVPS
GFECHCPPGW SGPTCAKDTD ECVSDPCAHG GTCIDMENDF ECLCTSSWTG KTCQIDINEC
AGKPCLNAYS CKNFIGGYHC ICFRGWGGQN CDIYLNSCHG QCQNGGTCMD MAKGYQCVCQ
PGFVGRHCEV QRNLCSSSPC KNGGQCHALL DHFLCQCLQG FTGATCEVQN DPCWPNPCHN
KAQCFSRLND FYCSCSNEYE GKTCSELKDH CKTNTCLVID SCTVGVFTND TQQLVISSNV
CGSHGRCISL TAGDFTCSCD PGFTGSNCHE NINDCASNPC KNGGTCIDGI NSFQCVCPGG
WEGPLCDADV DECSGLPCQN GGQCVDLLND FYCMCVDNWK GKTCHSRESQ CDSNTCSNGG
TCYDHGDSFM CSCPAGWGGH TCSTGKNNSC DSNPCVNGGT CVGAGDSFTC ICKEGWVGLT
CTQNVDDCNP HPCYNGGTCI DGANWFRCEC APGFAGPDCR INIDECQSSP CADGSTCFDE
INGYLCICPP GQAGPRCQES MGLKKMCHHN GLQYPHDSEW EEECNTCQCV NGNVHCSKVR
CGRRPCLLPK SLSAAETNAQ ACPGGHDCIQ HQFLTCFSPP CRQWGVCSTP DPPTALHTQC
EPNSGYLDNS CAHITLIFKK DRVPQGTTVE SICWELKYLP VTRILAKEHV LLILCDLSYL
RSDAVEVAMS FERTESDCKQ VEKAVNALTG ALSKHQNSSI FSAVMEVNVE MRVECPSVGY
LVPVLCVVFS LLWIFCIVIC VWWIQRRKKE RERPRSEEIQ VNNQLDQSNA PKENRDLDFY
YECKKLMSPS DRTCDEVEGE REEEHSGESQ EGEERVVLGV ENKLSQQKCF VKESQNTVVL
IKRGMICTSH SGPGNLLQQM AYSPKDNRCK NLNAARLSED VKDQYV
//