ID A0A3B3D254_ORYME Unreviewed; 1788 AA.
AC A0A3B3D254;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Laminin subunit beta-4-like {ECO:0000313|Ensembl:ENSOMEP00000024212.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000024212.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000024212.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR STRING; 30732.ENSOMEP00000024212; -.
DR PaxDb; 30732-ENSOMEP00000024212; -.
DR Ensembl; ENSOMET00000010237.1; ENSOMEP00000024212.1; ENSOMEG00000004714.1.
DR GeneTree; ENSGT00940000165244; -.
DR OMA; RRCSCHP; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd22301; cc_LAMB4_C; 1.
DR CDD; cd00055; EGF_Lam; 11.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 11.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013015; Laminin_IV_B.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF435; LAMININ SUBUNIT GAMMA-1; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 12.
DR Pfam; PF21199; LAMININ_IV_B; 1.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00180; EGF_Lam; 13.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 12.
DR PROSITE; PS01248; EGF_LAM_1; 5.
DR PROSITE; PS50027; EGF_LAM_2; 8.
DR PROSITE; PS51116; LAMININ_IVB; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1788
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017334144"
FT DOMAIN 28..268
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 399..450
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 451..499
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 539..804
FT /note="Laminin IV type B"
FT /evidence="ECO:0000259|PROSITE:PS51116"
FT DOMAIN 810..857
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 858..903
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 904..951
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1012..1063
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1064..1120
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1121..1168
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT COILED 1318..1345
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 421..430
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 471..480
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 483..497
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 810..822
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 812..829
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 831..840
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 858..870
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 860..877
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 879..888
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 923..932
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 935..949
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1036..1045
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1093..1102
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1121..1133
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1123..1140
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1142..1151
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 1788 AA; 197807 MW; 5C45F3E9C143A3A7 CRC64;
MKKMVIFLAV FFPAVHFHSL SDLQDQCPSA PCEPPLGDLM VGRQAQLKAS STCGLKGPEQ
YCTTGHLQEA RNCFLCDSQL PYSYHSNRNS HWIENIIMSS DPDKNMSWWQ SQNGVHQVSI
QLDLETVFQF SHLVLTFKSF RPAAMVVERS KDFGQTWKIF RFFADDCALH FPSVLRGPAS
SIADIICDSR FSGPEPSTGG EVVLQALDPM FEIADPHAAI IQDLISMTNI RLNFTRLLTL
KDTLPARRQR SPVDNYYYAL FNMVIRGSCF CNGHATQCMP IYREQGNVVT QSGKVHGRCV
CHHNTAGHNC ERCQEFHHDT PWSPGGETSA RVCRKCNCHG HSEACHFDAA RYQLTGGVSG
GVCDNCQHYR TGAQCERCQT YMYQDPEKTM DDPRSCIPCD CDPDGSHGGG LCDALTGQCF
CKENVEGWRC DRCKQGFFGL RRENPSGCYE CHCHTLGSVA SCDPLTGNCK CDSLAYGPHC
DRCVTGFWGL GNSTIRCSPC DCDIGGAHNT RCSSENGQCH CLPNMIGRTC SEPAHGHFLP
PLNYFLYEAE LAAPLPEIRL SPSMPTSSSV QSPKVLPPCE QYFKERGFDF SFSSGQIVLV
QRAHQLRSPH KRQLQNIIPL VPGYASQIIP GQKSSDQKVK STGLGLVRVL EGTGLTFTVD
NLPSSMKYHL VIHYEQETLS DWLATISIRM LLPGDKGCSK DSIERMLLNL PDTSRAGILD
SPVCLNAGAL YLVEVLFYSQ PTTEGLHILV DSMGLIPSVE SIQDCSQKTL QPFHCTGLAI
SPDSQESLPE VCERLIKSLS ARIHYGATAC ECNLTGSLGP ACSKLGGFCE CKPNVIGRCC
DTCAPLTFGF GSEGCERCEC DPRGSSSKWC DQVEGQCMCY SGVVGRRCDH CKAGFWGFPY
CRPCECGGRS ETCHGETGAC VNCREHTTGG HCDRCAEGYY GNPISRQPCQ PCLCPGTLRS
GHFFATSCQQ DSQSLGVSCD CLVGHTGSRC EICLPGFFGD LTAPGFSHCR PCLCNSNTSP
DDLYPCDRKT GECLHCLHNT SGPQCQACKP GYYGNALTQD CKECSCYRKG TVVSQCPAHG
PCFCNPRTGQ CPCRRGTEGD LCDRCEDGYW DLDGWGGCQP CSCHPEHSMS NKCDKVTGQC
HCHPEFGGQQ CNMCGENYFG SPELQCFPCD CHLEGTERPS CDPETGECIC GSGISGILCD
ECSPGYDATF PACKICHSCA SLWAEEITDV QKAARRMKTF IPQPNGTLQQ TISSQQQRIL
DGYFTVGSLV KIMLMFLPRL QKLDKLCVQI RMLKDSIDTN TILIDPSALL FIEIHGTKQQ
SKNLLNNLKD NLIKGKDEER DVKKELLLQI LKHHKSFMLN EEGLRNFSTT LENSMDTRHE
VLRKLSRCSR IGALAKLEQK VKDLSVVTFN HKASKRPCLK NCSVDGAAPC VLLLGGPDCD
GGVSISHIAL STLEKAKDQL IGFQAKLQRA EKKIYNALKL AQTIKDHAKT LQTQLISNAV
TLQRKKTHTR DLFQRAKLLI TDNTVSPDDI KEMATDVLSI HLSLSPDEIW SVINVSNNLT
SKSGKVQYNL TDLKNQAAVG QGLLHKVQYS RQQTAGMDIK NINIDIFKVH RSNSRTSENL
TKATGDQNNA DSHMKDVESK LDSIKSKLEK APDLSTEIKN VKDKTEQTNF LVTEATDAAE
DGFNDIVDAQ GTFRLVMKLF WAFKKETSAL KLAANTPHQL TKIAKGAKDF EKEVEDKFKQ
TQDVEQRIKW LLNRKKQKEL QLFQLLKIVY SLRQDILSRV VSYSTCSS
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