ID A0A3B3D3A6_ORYME Unreviewed; 195 AA.
AC A0A3B3D3A6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Apoptosis-associated speck-like protein containing a CARD {ECO:0000313|Ensembl:ENSOMEP00000024351.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000024351.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000024351.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Inflammasome {ECO:0000256|ARBA:ARBA00004110}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3B3D3A6; -.
DR STRING; 30732.ENSOMEP00000024351; -.
DR PaxDb; 30732-ENSOMEP00000024351; -.
DR Ensembl; ENSOMET00000009890.1; ENSOMEP00000024351.1; ENSOMEG00000004943.1.
DR GeneTree; ENSGT00940000164898; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0061702; C:canonical inflammasome complex; IEA:UniProtKB-SubCell.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08330; CARD_ASC_NALP1; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR033516; CARD8/ASC/NALP1_CARD.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR PANTHER; PTHR46985:SF2; APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD; 1.
DR PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50824; DAPIN; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023233};
KW Inflammasome {ECO:0000256|ARBA:ARBA00023233};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198}.
FT DOMAIN 7..92
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 106..195
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
SQ SEQUENCE 195 AA; 22576 MW; 6FEEE45B54664A82 CRC64;
MKSQRLFTDL TETNFQKFVQ DLVDRRQEPR VRRARVDGKG FLVVADVMVS TFTEKKVLSV
AAEILRGIGC SEEAQQRKTF RFDGLAQKGR LSDTFSFFHF LFPAERGAAQ QHFVDKHFSE
LIDRVTCVEP ILDLLLQKEV LQHEAYNSIR SMPTPQAKMR ELLIHLRASP AHKDIFYDIL
KKQQKHLVED LEGNS
//
