ID   A0A3B3D893_ORYME        Unreviewed;       955 AA.
AC   A0A3B3D893;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Epidermal growth factor receptor pathway substrate 15-like 1a {ECO:0000313|Ensembl:ENSOMEP00000026323.1};
GN   Name=EPS15L1 {ECO:0000313|Ensembl:ENSOMEP00000026323.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000026323.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000026323.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B3D893; -.
DR   STRING; 30732.ENSOMEP00000026323; -.
DR   PaxDb; 30732-ENSOMEP00000026323; -.
DR   Ensembl; ENSOMET00000004849.1; ENSOMEP00000026323.1; ENSOMEG00000008128.1.
DR   GeneTree; ENSGT00940000155438; -.
DR   OMA; AMYLVRQ; -.
DR   OrthoDB; 12127at2759; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00052; EH; 3.
DR   Gene3D; 1.10.287.1490; -; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 3.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR000261; EH_dom.
DR   InterPro; IPR003903; UIM_dom.
DR   PANTHER; PTHR11216; EH DOMAIN; 1.
DR   PANTHER; PTHR11216:SF69; EPIDERMAL GROWTH FACTOR RECEPTOR SUBSTRATE 15-LIKE 1; 1.
DR   Pfam; PF12763; EF-hand_4; 3.
DR   SMART; SM00054; EFh; 4.
DR   SMART; SM00027; EH; 3.
DR   SMART; SM00726; UIM; 2.
DR   SUPFAM; SSF47473; EF-hand; 3.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50031; EH; 3.
DR   PROSITE; PS50330; UIM; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT   DOMAIN          50..139
FT                   /note="EH"
FT                   /evidence="ECO:0000259|PROSITE:PS50031"
FT   DOMAIN          160..248
FT                   /note="EH"
FT                   /evidence="ECO:0000259|PROSITE:PS50031"
FT   DOMAIN          192..227
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          306..341
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          307..397
FT                   /note="EH"
FT                   /evidence="ECO:0000259|PROSITE:PS50031"
FT   REGION          235..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          639..938
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          439..606
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        269..293
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        717..731
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        736..772
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        780..796
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        837..851
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        914..938
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   955 AA;  105108 MW;  5979FE4C0913E2E8 CRC64;
     MLHYRDDSAL QRLSQRRPAG GAAVQREAER VPAATGKMAA LTSLTQLSSG NPIYESFYRQ
     VDPGNLGRVG PTEAALFLKK SGLADVTLGK IWDLADPDGK GYLDKQGFFV ALRLVACAQN
     CHEVSLSSLN ISVPPPKFKD TSSPSLSSTP SDHWAVRPEE KSKFDGIFES LVPTGGLLSG
     EKVRPVLINS KLPLDVLGKV WDLSDIDKDG HLDRDEFAVA MHLVYRALEK EPVPAVLPPS
     LVPPSKRKKS LCSVPGLPAS PPPPKDSLRS TPSHGSMTSL NSAGSLSPKH TLKSGQHSLN
     WVVPVSERGR YDDIFLKTDT DLDGFVSGQE VKDIFMQSGL SQNVLAHIWA LADTRQIGKL
     TREQFSLAMH LIQQKVSKGI DPPQALSADM IPPSERATPV PAVSGFVTPV GSDVAALSEM
     RRDSSSSVGS GEFTGIKELD DISQEISQLQ REKYTLEQDI RETEEAIRQK SAEVQEMQND
     LDRETVTLQE LEAQKQDAQD RLDEMDQQKH KLEDMLNEVR MKCQEESQMI STLQSQIHCQ
     ESDLLSQEEE LSRAKTDLNR LQQEESQLEQ SLAAGKIQLE TIIKSLKATQ DEINQARSKL
     AQIQDSQQEV TRSIEQYSSS LNGAHGGSMT NLADMSEAFT DRDTGGFPAL GRLPQEDPFK
     VKPPFSSQPQ ELQDPFHSED PFKTDPFKGD PFQNDPFAKQ PSSSADPFGG DPFKDPDPFK
     ASSEDFFKKT TKIDPFSTPD PFSKSATLPS KQTTHLTAAD PFSSSHQRSR GPDVFQTLDP
     FGSGSFSTNS SAGFADFSHM SKPRDPFEGR AGWLPDYQKS AFVDDPFSRR SDMPALPPKK
     SVPPRPKPPS GKTTPVGLVE SSKPGDPFQP FSSEVIDPFM SKKGPVDPFS GKDPFTPSSA
     SRPDKVKLGN EAQQLEWAKR ESERAERERL KRLRQQEQED LELAIALSKA EMSNA
//