ID A0A3B3DAF8_ORYME Unreviewed; 435 AA.
AC A0A3B3DAF8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=UDP-sugar transporter protein SLC35A5 {ECO:0000256|ARBA:ARBA00040377};
DE AltName: Full=Solute carrier family 35 member A5 {ECO:0000256|ARBA:ARBA00041937};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000026876.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000026876.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Probable UDP-sugar:UMP transmembrane antiporter involved in
CC UDP-alpha-D-glucuronate/UDP-GlcA, UDP-GlcNAc/UDP-N-acetyl-alpha-D-
CC glucosamine and UDP-N-acetyl-alpha-D-galactosamine/UDP-GalNAc transport
CC from the cytosol to the lumen of the Golgi.
CC {ECO:0000256|ARBA:ARBA00037779}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-N-acetyl-alpha-D-galactosamine(in) + UMP(out) = UDP-N-
CC acetyl-alpha-D-galactosamine(out) + UMP(in); Xref=Rhea:RHEA:72735,
CC ChEBI:CHEBI:57865, ChEBI:CHEBI:67138;
CC Evidence={ECO:0000256|ARBA:ARBA00036186};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out) = UDP-N-
CC acetyl-alpha-D-glucosamine(out) + UMP(in); Xref=Rhea:RHEA:72695,
CC ChEBI:CHEBI:57705, ChEBI:CHEBI:57865;
CC Evidence={ECO:0000256|ARBA:ARBA00036522};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-alpha-D-glucuronate(in) + UMP(out) = UDP-alpha-D-
CC glucuronate(out) + UMP(in); Xref=Rhea:RHEA:72727, ChEBI:CHEBI:57865,
CC ChEBI:CHEBI:58052; Evidence={ECO:0000256|ARBA:ARBA00036726};
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC subfamily. {ECO:0000256|ARBA:ARBA00009976}.
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DR AlphaFoldDB; A0A3B3DAF8; -.
DR Ensembl; ENSOMET00000003412.1; ENSOMEP00000026876.1; ENSOMEG00000009027.1.
DR GeneTree; ENSGT00950000182827; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR007271; Nuc_sug_transpt.
DR PANTHER; PTHR10231; NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER; 1.
DR PANTHER; PTHR10231:SF90; UDP-SUGAR TRANSPORTER PROTEIN SLC35A5-RELATED; 1.
DR Pfam; PF04142; Nuc_sug_transp; 1.
DR PIRSF; PIRSF005799; UDP-gal_transpt; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 25..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 64..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 410..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 435 AA; 48327 MW; 91B0DBF719927B1B CRC64;
MVQQVRVSAM VCCPPCPRLC SRSSAYTLLL GLCFVTLGTS RILLLKFSAN ADNQYDFLPA
SVNLLAEALK LLFCVVMSVR VIVREGRSFR SLGSTSSSSL LNSIKWSVPA FLYFLDNIII
FYVMTYLQPA MAVLFSNVVI LTTAVLFRIV LKRRLSWVQW AALVILFLAI VSLTTGSGSK
QNSTVVSSLH SNPLFLPSNS CLLYTQLLDQ MKNSSASAAW TSSLPGQAWK EQMLDKLRYL
GVGHILLLLQ CFISSMANIY NEKILKEGDQ LTESIFIQNS KLYAFGVVFN GFTLGLGSEA
RGRTLHCGLL YGHNVYSLGL VLVTAALGLS VAFILKFRDN MFHVLTGQIT TVLVTAISLF
CFNFHPSLDF FLQAPMVLLA IFIYNASRPK DLEYSLQQEK LRVINGEVSE RSRGDGEELE
LLTRMETDSE SEESL
//
