ID A0A3B3DBG7_ORYME Unreviewed; 828 AA.
AC A0A3B3DBG7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=ABR activator of RhoGEF and GTPase {ECO:0000313|Ensembl:ENSOMEP00000026730.1};
GN Name=ABR {ECO:0000313|Ensembl:ENSOMEP00000026730.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000026730.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000026730.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendritic spine
CC {ECO:0000256|ARBA:ARBA00004552}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
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DR AlphaFoldDB; A0A3B3DBG7; -.
DR Ensembl; ENSOMET00000003774.1; ENSOMEP00000026730.1; ENSOMEG00000008951.1.
DR GeneTree; ENSGT00940000153491; -.
DR OMA; TMFYKIP; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08686; C2_ABR; 1.
DR CDD; cd04387; RhoGAP_Bcr; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR037769; Abr/Bcr.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23182:SF5; ACTIVE BREAKPOINT CLUSTER REGION-RELATED PROTEIN; 1.
DR PANTHER; PTHR23182; BREAKPOINT CLUSTER REGION PROTEIN BCR; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658}.
FT DOMAIN 53..251
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 268..426
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 451..580
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 614..814
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
SQ SEQUENCE 828 AA; 94653 MW; B091DB9FFAB0D07F CRC64;
GKSQDGSETL PYIDESPTMS PQLCVAQGPD GEVISPTPPE GLHEGDLEKG LEMKKLVLSG
FLTSEEIYIN QLEALQLPLR PLKATATTSQ PVLTMQQIDT IFYKIQDILE IHKEFFDALL
PSIQQWDEKV TVGHLFKKLA SQLGVYKAFV DNYKIALETA EKCSQANMQF QKISEVRNLT
CHVCVFVWIR YTDSFISSPT ALLYKPIDRV TRSTLVLHDL LKHTPKDHPD FPLLQDALRI
SQNFLSSINE EIDPRRTAVT TPKGEARQLV KDGFLVEVSE SSRKLRHVFL FTDLLLCAKM
KKTSVGRHQQ YECKWYIPLA DLTFQTPDDS DPCPSIQVLP EHEIEEMKMK ISVLKNDIQK
EKKAPKGQNR AERLRKKMNE QESWLLLHSP TIPFRVHNKH GKSFLFLLSS DYERSEWRES
IQKLQKKDLQ VCILTTYELQ VLTNSCVKLR TVHNIPVTGN KDDEESSGLY GFLHVIVHSA
KGFKESANLY CTLEVDSFGY FVSKAKTRVF RDTTEPLWNE EFEIELEGSQ YLRILCYEKC
YDKSMLNKDD NEIVDKIMGK GQVQLDPQTV QSKNWQVDVI EMNGIKVEFS MKFTSRDLSL
KRTPSKKQSG VFGVKINVVT KRERSKVPYI VRQCIEEVEK RGIDEVGIYR ISGVATDIQA
LKSAFDTNTK DILVMLSDMD INAIAGTLKL YFRELPEPLL TDRLYPAFME GIALSDPAAK
ENCMMHLLRT LPDPNIMTFL TLLEHLKRVA EKEPVNKMSL HNLATVFGPT LLRPSESESV
KGQHITSASD IWSHDVMAQV QVLLYYLQHP PISFAELKRN TLYFSTDV
//
