ID A0A3B3DBJ8_ORYME Unreviewed; 1411 AA.
AC A0A3B3DBJ8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
GN Name=ERBB3 {ECO:0000313|Ensembl:ENSOMEP00000027271.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000027271.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000027271.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. EGF receptor subfamily. {ECO:0000256|PIRNR:PIRNR000619}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 30732.ENSOMEP00000027271; -.
DR PaxDb; 30732-ENSOMEP00000027271; -.
DR Ensembl; ENSOMET00000002401.1; ENSOMEP00000027271.1; ENSOMEG00000009645.1.
DR GeneTree; ENSGT00940000156107; -.
DR OMA; AVMLNYQ; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0042127; P:regulation of cell population proliferation; IEA:UniProt.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:UniProtKB-UniRule.
DR CDD; cd00064; FU; 4.
DR CDD; cd12095; TM_ErbB3; 1.
DR Gene3D; 6.10.250.2930; -; 1.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR044912; Egfr_JX_dom.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
DR PANTHER; PTHR24416:SF88; RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR PIRSF; PIRSF000619; TyrPK_EGF-R; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00261; FU; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR000619};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR000619};
KW Membrane {ECO:0000256|PIRNR:PIRNR000619, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR000619};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR000619};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000619};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|PIRNR:PIRNR000619}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1411
FT /note="Receptor protein-tyrosine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017365667"
FT TRANSMEM 654..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 716..973
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1069..1222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1244..1311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1069..1091
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1106..1120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1192..1222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1244..1269
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 722..730
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2"
FT BINDING 749
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1411 AA; 158125 MW; CCC2A3D53E89CED7 CRC64;
MSRFQRRGAQ VLCALLCALQ LCSAQTQKIC PGTQNGLSSP RDSEIQYNLI KDMYTGCNIV
MGNLEITMME HYRDFSFLQS IKEVTGYVLF ALNEFSRLPL DQLRVIRGNT LYDNQYALAV
MINYQKNGQH GLQELGLTHL TEILRGGVKI IQNKFLSYAP QVNWDDIVKE GPIHNVFEEN
GPEKPCHESC KGVPCWGPGS DKCQILTQTV CAPQCNSRCF GTNPNECCHP ECAGGCKGPL
DTDCFACKNF NNLGSCVPQC PQALIYNRHT FRMEPNPDAK YQFGSLCVAQ CPANFLVDGS
SCVSSCPSDK KEVEKNGVKR CDPCVGLCPK ACQGTGGPGR ETVDAHNIDS FINCTKIQGS
LHFLVTGIHG DVFNNIPPLN PEKLKIFETV EEITDYLSIQ SWPESLSNLS VFSNLRVIQG
RTLYKGVSKR GYSLMVMKIK SLSSLGFRSL QKVNDGVVYI TGNKKLCYQD TVNWTRILNN
RPRQKRQKFV EVKDNRPSND CVEEGRVCDP LCSADGCWGP GPDQCVSCKN YSRGGVCVPD
CMFLSGEQRE FATPTGECQL CHSQCQIQKG GTTCTGPGAN QCVACAELKD GPHCVSSCPK
GVMGEEGIIF KYSDKNKKCE QCHVNCTEGC TGPGLENCIG ASPRVFSRQA TTGIVLGLIA
FIFVSFSVMT LTFLYRRGLA IRRKRAMRRY MESGEHFEPL EEKEKVYARI LKPADLRKIK
LLGNGAFGSV HKGIWIPEGD TVKLPVAIKT VHDRTGRQTF FEITEHMKAI GSLNHINVVK
TLGICPGESL QLITQLSTQG SLLEHIRNNK NKLSPQRLLN WCVQIAKGMN YLEDNKMVHR
NLAARNVLLN NNFTAQISDY GIADLLCPED KKYFYNEVKT PIKWMALESI FFRRYTHQSD
VWSYGVTVWE MMSYGAEPYA NMRPQEVPDL LEEGERLSQP SICTIDVYMV MVKCWMIDEN
VRPTFKELAS EFTRMARDPP RYLVIKEDCS QQQSGLDEVT QRSADLDDLD DLDIDIEDLV
VEEDVDAPAP PYLSRSISRL SKTDTHKLVL NPSIGAGYLP MTPGADHAVQ SSWQSRSRLN
SARTVSESSE GCGTAVELDM SEDFSMAGSL KRKRQRQDSA YVSQRDSMSG GPPETPSPDE
DDENDEYVLP GNSPERDNLL TSYRATPGRM GKSRSGSLLD NPDEDYEYMN KQMSLTPVSL
RHNNQRQKPN KKRTSSVSSQ ATACSFETTQ SLEVKGRRIS FESELQETSR VEYEDMDIRS
IERDESPPAH EPPPPPILER RQRKVEEEQE EEEYMEDDNY HYTNQQPKLR QTLQDKKELK
INRRDKNETY EYEDMDYFTA PPPADAGLYQ NMQKDTGEAV GATSGHFSGC DPHENVRAGL
GVGEPAAGDT SFDNPAYWHS KMFHNPSAVP I
//
