ID   A0A3B3DC13_ORYME        Unreviewed;       424 AA.
AC   A0A3B3DC13;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Syndecan {ECO:0000256|RuleBase:RU000649};
GN   Name=SDC3 {ECO:0000313|Ensembl:ENSOMEP00000027039.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000027039.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000027039.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Cell surface proteoglycan. {ECO:0000256|RuleBase:RU000649}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC       ECO:0000256|RuleBase:RU000649}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU000649}.
CC   -!- SIMILARITY: Belongs to the neurexin family.
CC       {ECO:0000256|ARBA:ARBA00010241}.
CC   -!- SIMILARITY: Belongs to the syndecan proteoglycan family.
CC       {ECO:0000256|ARBA:ARBA00005343, ECO:0000256|RuleBase:RU000649}.
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DR   AlphaFoldDB; A0A3B3DC13; -.
DR   STRING; 30732.ENSOMEP00000027039; -.
DR   PaxDb; 30732-ENSOMEP00000027039; -.
DR   Ensembl; ENSOMET00000002983.1; ENSOMEP00000027039.1; ENSOMEG00000009263.1.
DR   GeneTree; ENSGT00940000160209; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR003585; Neurexin-like.
DR   InterPro; IPR001050; Syndecan.
DR   InterPro; IPR027789; Syndecan/Neurexin_dom.
DR   InterPro; IPR030479; Syndecan_CS.
DR   PANTHER; PTHR10915; SYNDECAN; 1.
DR   PANTHER; PTHR10915:SF7; SYNDECAN-3; 1.
DR   Pfam; PF01034; Syndecan; 1.
DR   SMART; SM00294; 4.1m; 1.
DR   PROSITE; PS00964; SYNDECAN; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180,
KW   ECO:0000256|RuleBase:RU000649};
KW   Heparan sulfate {ECO:0000256|ARBA:ARBA00023207,
KW   ECO:0000256|RuleBase:RU000649};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Proteoglycan {ECO:0000256|ARBA:ARBA00022974,
KW   ECO:0000256|RuleBase:RU000649}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000649};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..424
FT                   /note="Syndecan"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017255810"
FT   TRANSMEM        358..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          390..408
FT                   /note="Neurexin/syndecan/glycophorin C"
FT                   /evidence="ECO:0000259|SMART:SM00294"
FT   REGION          17..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          72..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          224..251
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          274..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        108..168
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        176..197
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        224..250
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        274..296
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   424 AA;  46096 MW;  552AF9253C83DBC4 CRC64;
     MKLPVLLALT ALLAGAATGQ TRSPSIDDEG SAGDLYDDDD LYSGSGSGFS EITIRPTSVG
     VSFTTEEPLV FSTTQATSPA PSASPAAEPS PIPEDVSTTP LPTEADEESG AFWDREKERE
     MEREKERQME KERQKELERE RERERERERE RQRERELERE RERERIRAAA QTTAAPRSPG
     VLSVVTSSPT AGTAESAAPS AGSDDLTFFT TEEGDFNLPT ETTSFYPGFD LESVTDEDTP
     TTTEPTPEPT TAARTVRAWV PFRPRVPITT ATKAAPTERT TRPQPPTTTQ EGNNEVGAVG
     PSGDFEIRIG LGEEPPMEPD LTGNTVDVGA GSSSAAQLPQ KNILERKEVL IAVLIGGLLA
     MVFADFLVIA VIVGGVVGAL FAAFLVMLLV YRMKKKDEGS YTLEEPKQAT VTYQKPDKQE
     EFYA
//