ID   A0A3B3DCZ1_ORYME        Unreviewed;       458 AA.
AC   A0A3B3DCZ1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Si:dkey-103i16.6 {ECO:0000313|Ensembl:ENSOMEP00000027962.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000027962.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000027962.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B3DCZ1; -.
DR   Ensembl; ENSOMET00000000628.1; ENSOMEP00000027962.1; ENSOMEG00000010742.1.
DR   GeneTree; ENSGT00940000165765; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   CDD; cd01408; SIRT1; 1.
DR   Gene3D; 3.30.1600.10; SIR2/SIRT2 'Small Domain; 1.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR003000; Sirtuin.
DR   InterPro; IPR026591; Sirtuin_cat_small_dom_sf.
DR   InterPro; IPR026590; Ssirtuin_cat_dom.
DR   PANTHER; PTHR11085; NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED; 1.
DR   PANTHER; PTHR11085:SF8; NOVEL PROTEIN SIMILAR TO VERTEBRATE SIRTUIN (SILENT MATING TYPE INFORMATION REGULATION 2 HOMOLOG) 2 (S. CEREVISIAE) (SIRT2); 1.
DR   Pfam; PF02146; SIR2; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   PROSITE; PS50305; SIRTUIN; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00236};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00236}.
FT   DOMAIN          124..390
FT                   /note="Deacetylase sirtuin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50305"
FT   REGION          44..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          96..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          404..458
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        404..422
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        257
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         265
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         268
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         289
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         292
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
SQ   SEQUENCE   458 AA;  50310 MW;  7AB1A176B7D87969 CRC64;
     MVTPSNIHAL PAADYLHQVC FAERSGMNRS RSCVVRPPIA RVTRSAKSQA AHPKPTEIQD
     SEEGLYGKHK KIQMDSTPAA DLCHMSVETQ DIFITSKASD SSGDPLPACQ TSGSKADRGS
     PSSRGVKSSS PHDLLSVARL VKLGRCKNVV VVAGAGISTA SGIPDFRTPG TGLYSNLEKY
     NVPYPEAIFN IDYFSDNPQP FFSLAKVLYP GSHRPNYIHY FIRMLHHKGL LLRMYTQNID
     GLEKLCGIPD DKLVEAHGSF ATASCHLCYT PYPAEEARYA IMHDRVPTCS FCAATVKPDV
     VFFGEDLPRK YFLHRKDFPK ADLLIIMGTS LKIEPFASLI NSVRSTVPRL LLNRNAVGPF
     ERIPLRRGDH MELGDLADSV RKFAELLGWD GEIQELMGSQ EVESPMLLSS PSSQSRLPFQ
     NGVPSDHESC EETSRAASSR VSSSNEETDS ETDSKSSA
//