ID A0A3B3DH54_ORYME Unreviewed; 201 AA.
AC A0A3B3DH54;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=TNFR-Cys domain-containing protein {ECO:0000259|PROSITE:PS50050};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000029432.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000029432.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR AlphaFoldDB; A0A3B3DH54; -.
DR STRING; 30732.ENSOMEP00000029432; -.
DR PaxDb; 30732-ENSOMEP00000029432; -.
DR Ensembl; ENSOMET00000018906.1; ENSOMEP00000029432.1; ENSOMEG00000013077.1.
DR GeneTree; ENSGT00940000155167; -.
DR OMA; GTHITEY; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR PANTHER; PTHR23097; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER; 1.
DR PANTHER; PTHR23097:SF181; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 21-LIKE-RELATED; 1.
DR Pfam; PF00020; TNFR_c6; 3.
DR SMART; SM00208; TNFR; 4.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00206}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..201
FT /note="TNFR-Cys domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017337122"
FT REPEAT 66..107
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 66..107
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 108..144
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 108..144
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 67..82
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 89..107
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 126..144
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 201 AA; 22194 MW; F3CFA1AFECE2ACE1 CRC64;
MCFKLWSSLQ LFLAVLLLLP ALLCKEDAVS TYCDPSTGEI LTCKKCEPGT YMAAHCTATT
DTKCLPCRAN HYTALWNYLP RCLYCNNICT RNQEVEIQCS ATNNRVCRCK QGYYMKDDFC
ISHSQCGPGH GVQTKGTSKQ DTVCEKCAHG FSSRSTSALD VCVKHQECAD GQLPLFTGPV
YHDALCGSCE DLASDSKYSE C
//
