ID   A0A3B3DHF7_ORYME        Unreviewed;       818 AA.
AC   A0A3B3DHF7;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Active breakpoint cluster region-related protein-like {ECO:0000313|Ensembl:ENSOMEP00000028845.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000028845.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000028845.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, axon
CC       {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendritic spine
CC       {ECO:0000256|ARBA:ARBA00004552}. Synapse
CC       {ECO:0000256|ARBA:ARBA00034103}.
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DR   AlphaFoldDB; A0A3B3DHF7; -.
DR   STRING; 30732.ENSOMEP00000028845; -.
DR   PaxDb; 30732-ENSOMEP00000028845; -.
DR   Ensembl; ENSOMET00000017771.1; ENSOMEP00000028845.1; ENSOMEG00000012137.1.
DR   GeneTree; ENSGT00940000153491; -.
DR   OMA; QDQYRFC; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR   GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR037769; Abr/Bcr.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR23182:SF6; ACTIVE BREAKPOINT CLUSTER REGION-RELATED PROTEIN-LIKE; 1.
DR   PANTHER; PTHR23182; BREAKPOINT CLUSTER REGION PROTEIN BCR; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658}.
FT   DOMAIN          60..263
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          458..573
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          606..800
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
SQ   SEQUENCE   818 AA;  92979 MW;  AAC7CA7E4476CD5F CRC64;
     MDVYREAVDY LESQHVAEAD IMEEDVFHEE AVSSFLSTMN IESIDLPDTP LFSPEEMLEK
     RLVVIKGILE SEELYLAELD TLLMPMKALR ASAGTSQPVL SNQQIQTVFY QVPELRDVHR
     TFYSDLKARL DTHYQDQLSE ELGKRYFELE VGDLFQRLVN HIGLYGGFIE NYEKAVEVVR
     KCTNSDPRFR TLAESMMSTN GTDKARTKYT FEALLYKPLD RVTKTTLVLG DLLKTTPVEH
     RDYAALQEAL RLSRSFLSGV NESSQSKRDV TLSHDMRRQL MRDGFVVDSS EGHRSLRHLF
     LYTDLLLCTR FKHATRGKQD QYRFSWYLPL AGLKLCWVAE QERAPDMNVR LHNIRTKMHL
     LRQQLKQHSR ASRGLVFTAR NKKKLEELEL MLFTHSPLYR LELFSSSGKS HTLLFSSLYE
     LEEWRENIYK LTSGTIETVP PDLLTLTGAC VKLRMTQQPP LHSLNSGNDR DSLCGTLTVA
     IHSASGLQQP AGVYVCVEVD GFEYYDRQAQ THSSVHSLNP HWDQELSFQV DGAQSMRLVC
     VSQRNGEDDA VLGKTTVKLE SKTLSERWRR QTLRLGQVDL AISLKYSPHP LEPPSSAVQQ
     LPLFGVPIEK VAQQEGVLVP HVVRCCVEEV ERRGMREVGI YRISGTSSDI NVLKAAFNSN
     LREAVSRLRN AEVNSVSGVL KLYLRELPEP LIPAELFQSL AENLNIQDED SRQASMLSLL
     QSCPHTNQNT FLYLMHHLQR VADMQDVNKM TLLNLATVFG PSLLRPPVAG LNGPALDISH
     EVVVQVQVVL CYLQCNNLPE AQTSLPRDAD AEEETTHM
//