ID A0A3B3DHH5_ORYME Unreviewed; 2187 AA.
AC A0A3B3DHH5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOMEP00000029346.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000029346.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000029346.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR STRING; 30732.ENSOMEP00000029346; -.
DR PaxDb; 30732-ENSOMEP00000029346; -.
DR Ensembl; ENSOMET00000018585.1; ENSOMEP00000029275.1; ENSOMEG00000012993.1.
DR Ensembl; ENSOMET00000018741.1; ENSOMEP00000029346.1; ENSOMEG00000012993.1.
DR GeneTree; ENSGT00940000154603; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.30.70.960; SEA domain; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008078; GPCR_2_Ig-hepta-like_rcpt.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR PANTHER; PTHR45813:SF4; ADHESION G PROTEIN-COUPLED RECEPTOR F5; 1.
DR PANTHER; PTHR45813; EF-HAND DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF01390; SEA; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01695; IGHEPTARCPTR.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF82671; SEA domain; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50024; SEA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1900..1919
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1940..1961
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1981..2006
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2018..2045
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2065..2089
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2110..2129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2141..2163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1239..1355
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 1333..1440
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1898..2164
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1094..1114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2187 AA; 237640 MW; B0020A3A3133B877 CRC64;
MYGACDQISE DSCGCIKAIP SDGNFCQSVD QHNFTACPTT TILASTYFST AATEIFTTTP
DVKTTATDFS STVPEIFTTK QDVTTTVTDP PPVYTYSISV ELNITDMKAI TKMRDILGTI
SYPYTISGNT QINQANISTV CSPVSDGYQC RCEDQYQWSC DQCQMYGACD QISENSCGCI
KAIPSDGNFC QSVDQHNFTL CPTTSTPSTI LSYTSLTPTE LFTTLPDMTT TMTEPPPAYR
YLISVELNTT ALTALNTLRS ILGNIVYPFS INSQTQINRA NISTVCFPVS DGYQCRCENQ
YMWSCDQCLT YGACDQISEN SCGCINSIPS DGNFCQSLDQ YNFTLCPTTT PTTVLTYSSS
TPTELFTTTA DVTTLTTAEP PPLYKYFLSV ELNTTDVIVI NKLRSILENI SYPLSINRQT
RINYANISTV CSPVSDGYQC RCEDQYQWSC DQCQMYGACD QISEDSCGCI KAIPSDGNFC
QSVDQNNFTL CPSAIPSTIS TYYSPTPTAL FTTTADVTTT MTEPPPLYRY FLSVELNTTD
VIVINKLRSV LENISYPLSI NSQTRINYAN ISTVCSPVSD GYQCRCEDQY KWSCDQCQMY
GACDQISENS CGCIKAIPSD GNFCQSLNQN NFTVCAPTPT PDPLLTSSPS VTTEIITTVP
DVTTTVTESP TVTTEILTTT VEVTTPTTDS PSVTTKVDTT TVDVTTTMTA EPPPLYKYVL
SVELNTTDVI VINKLRSVLE NISYPLSINS QTQINYANIS TVCSPVSDGY QCRCEDQYQW
SCDQCQMYGA CDQISEDSCG CVKAIPSDGN FCQSLYQNNF TVCPPTPTPI PLTTYLPSVS
TEIITTTVDV TTITVSPSVT TEAFTTAQQV TTTMTVSPSM TTEAFTTAQQ VTTTMTDSPS
VTTEIFTTVP DVTTIMTGSP SVTTKLFTTK ADLTTPTTDS PVTTKLFTTR ADVTTPTTEL
PLPVYNYRVS VELNTTEITV IDKLRSILGN ITYLPSISRL IRISWANIST VCSPVSGGYQ
CKCEDHYHWS CDQCQMYGAC DQISENSCGC VNAIPPDGDF CQPRDQLNLT ACLVETTTPS
TSTAWTSQSF KTTGDNSMTS VNTTETTNSS TPPIISPTTG VSTLIYTTTE DPTTASSTVT
LTTRDDTTTM MSTVSPTIME TTTAVSTVIS TTTEEPTTLV STVIHTTNEQ PTTPVSTVVS
TPTEETTARS TVTPSTTKTQ TSSVTMDFPI RTETTTKAVS KAIDIEVSVT FDMEFKDAFN
DKSSAEYKSL EDKISTELQR QYETITGFVR VIVTGFRRGS VIADFVISTA EGSATQITQA
NKNLTNTLKS IAPVLKSTAL YKSSRNITYI TYTPPILTGK TMELQCGPPD GDLLAIVGNI
KSAQWKADGI KILSGTRQTF TIVSNTSVLT VNNLINKDAG LYECILSGTN SDFYQNITVK
RDDIKAAPLL EMTPKLSVEC KTSTKVSLDC CVQSNYVASL VNPPTEVQIL EPTTSNEKYC
VKYEYTIPSC SSNPQPITFK CKVDGYNGYE KTTTLNFFTG APTCTSNIYG QGQEGATSTI
VCPGGTKTAQ CKAGSWIVIT DNCILPVIKD LLTESADLVP EKVETFSNDL KKTVKDNKTE
IAKSSKSVST IVDIVKTIAN VSTFVTTEII TNVLQTIDVL TDDSVKQSWE TLNKDRNDNA
ASRLLGSLET LSQALSGTAD VSTERIHLIR TNATEFKPSN STVSIEIQDS DGVFNNNTFM
TIIILNTFNN VMPARNSSFD LNLFNGTSNE TTSANNANLA INAAVVLVQV NQTVPSVNFK
FIALNENLTK ETQCVFWNFT LLENFGAWDD EGCKFVSREN DTVICNCSHL TSFSVLMSTD
ISLFVNKPPG SGSGSGGSSP GGSGGGQGAT ITAAGFILDI ITYIGVAISL ASLVICLIIE
GYVWRAVTKN TTALMRHISI VNTALSLLIA DICFIIAASY SQKAINNTDG DFKGLIGQCT
AVTFFMHFFY LALFFWMLVS GLLLFYRTVM VFSHMSKSIM IAIGFVVGYG CPLIIAVTTV
AATAPSQTYI RKNYICWLNW TESKALLSLV IPALVIVVIN IIVVIVVLCK MMRRSSGNTV
QPDEKNSFVV IIRCLAILTP LFGLTWALGI GTMVSPKDLG IHIAFAFFNS LQGFFILVFG
TLFDSKIRAL LSSRMPSTNS NSTGVSS
//
